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CCR4
chemokine (C-C motif) receptor 4
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
| Gene Name: | chemokine (C-C motif) receptor 4 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CCR4, C-C chemokine receptor type 4, CD194, CD194 antigen, C-C CKR-4, Chemr13, CKR-4, CC chemokine receptor 4, CC-CKR-4, CCR-4, HGCN:14099, C-c chemokine receptor 4, Chemokine (C-C) receptor 4, CKR4, CMKBR4, K5-5 |
| Target Sequences: | NM_005508 NP_005499.1 P51679 |
Publications (3)
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