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CCR4

chemokine (C-C motif) receptor 4

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Gene Name: chemokine (C-C motif) receptor 4
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR4, C-C chemokine receptor type 4, CD194, CD194 antigen, C-C CKR-4, Chemr13, CKR-4, CC chemokine receptor 4, CC-CKR-4, CCR-4, HGCN:14099, C-c chemokine receptor 4, Chemokine (C-C) receptor 4, CKR4, CMKBR4, K5-5
Target Sequences: NM_005508 NP_005499.1 P51679

Publications (3)

1
Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer. Yang Y, Du L, Yang X, Qu A, Zhang X, Zhou C, Wang C. PloS one. 2015 10:e0120059. (IHC; Human) [Full Text Article] [PubMed:25790118] [PMC:PMC4366399] Related Antibodies: LS-A351.
2
CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. Lei Wang, Mei Zhang, Yuntao Zhu, Xin Zhang, Yongmei Yang, Chuanxin Wang. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2019 Feb;77:426-432. [Full Text Article] [PubMed:30395826] Related Antibodies: LS-A351.
3
Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression. Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, Deng BP, Yan S, Sun JT, Du LT, Liu J, Wang QJ, Neckenig MR, Yang QF, Qu X. Cancer science. 2011 Jul;102:1264-71. [Full Text Article] [PubMed:21443538] Related Antibodies: LS-A351.

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Proteins (3)
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CCR4 (3)
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CCR4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus
44.9 kDa
100 µg/$1,293; 20 µg/$854
CCR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.2 kDa
20 µg/$150
CCR4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.2 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).