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CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
| Gene Name: | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CCR5, C-C chemokine receptor 5, CD195 antigen, CD195, C-C CKR-5, Chemokine c-c motif receptor 5, Chemr13, CMKBR5, CKR5, Cc chemokine receptor 5, CCCKR5, CCR-5, Ccr5 receptor, Chemokine receptor CCR5, HIV-1 fusion coreceptor, IDDM22, C-C chemokine receptor type 5, CC-CKR-5, CKR-5 |
| Target Sequences: | NM_000579 NP_000570.1 P51681 |
Publications (4)
1
Identification of a linear peptide recognized by monoclonal antibody 2D7 capable of generating CCR5-specific antibodies with human immunodeficiency virus-neutralizing activity. Khurana S, Kennedy M, King LR, Golding H. Journal of virology. 2005 79:6791-800. (Flo)
[PubMed:15890918]
[PMC:PMC1112162]
2
Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5. Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K. The Journal of biological chemistry. 2007 282:36923-32.
[PubMed:17971448]
Related Antibodies: LS-C40887.
3
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Fox JM, Letellier E, Oliphant CJ, Signoret N. Blood. 2011 117:1851-60.
[PubMed:21148810]
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CCR5 Mouse anti-Human Monoclonal (T21/8) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CCR5 Mouse anti-Human Monoclonal (aa1-22) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
Unconjugated
0.1 mg/$302
CCR5 Mouse anti-Human Monoclonal (aa1-22) (APC) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
APC Conjugated
100 Tests/$365
CCR5 Mouse anti-Human Monoclonal (aa1-22) (PE) (T21/8) Antibody
Human
ELISA, Flo, ICC, IP, WB
PE Conjugated
100 Tests/$365
CCR5 Rabbit anti-Human Polyclonal (aa19-34) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$575
CCR5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
CCR5 Rabbit anti-Human Polyclonal (aa19-34) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$723
CCR5 Mouse anti-Human Monoclonal (T21/8) Antibody
Human
ELISA, Flo, IF
Unconjugated
100 µg/$324
CCR5 Rabbit anti-Human Polyclonal (aa292-341) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
CCR5 Goat anti-Human Polyclonal Antibody
Human, Macaque
ELISA, ICC, IHC, WB
Unconjugated
100 µg/$556
CCR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
CCR5 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC
Unconjugated
60 µl/$307; 120 µl/$367; 200 µl/$457
CCR5 Rat anti-Human Monoclonal (FITC) (HEK/1/85a) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
CCR5 Rabbit anti-Human Polyclonal (aa180-229) Antibody
Human
WB
Unconjugated
100 µl/$424
CCR5 Mouse anti-Human Monoclonal (12D1) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated
20 µg/$371; 100 µg/$574
CCR5 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (12D1) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated, Azide-free, BSA-free
100 µg/$574
CCR5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
CCR5 Mouse anti-Human Polyclonal Antibody
Human
Flo, WB
Unconjugated
50 µg/$705
CCR5 Rabbit anti-Human Polyclonal (aa303-352) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCR5 Rat anti-Mouse Monoclonal (11D98) Antibody
Mouse
WB
Unconjugated
100 µg/$896
CCR5 Rabbit anti-Mouse Polyclonal (aa181-199) Antibody
Mouse
WB
Unconjugated
10 µg/$318; 100 µg/$470
CCR5 Mouse anti-Human Monoclonal (Phosphopeptide) (V14/2) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µg/$324
CCR5 Mouse anti-Human Monoclonal (6G11D1) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CCR5 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
CCR5 Mouse anti-Human Monoclonal (6H3D5) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
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of 108
product results
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