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CD1A

CD1a molecule

CD1A is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Gene Name: CD1a molecule
Synonyms: CD1A, CD1, CD1A antigen, a polypeptide, CD1a molecule, FCB6, HTA1, HTa1 thymocyte antigen, R4, T6, CD1a antigen, Cluster of differentiation 1 A
Target Sequences: M28825 AAA51931.1 P06126

Publications (2)

1
Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Patton KM, McGuire TC, Hines MT, Mealey RH, Hines SA. Infection and immunity. 2005 73:2083-93. [PubMed:15784549] [PMC:PMC1087435] Related Antibodies: LS-C40952.
2
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells. Curti A, Trabanelli S, Onofri C, Aluigi M, Salvestrini V, Ocadlikova D, Evangelisti C, Rutella S, De Cristofaro R, Ottaviani E, Baccarani M, Lemoli RM. Haematologica. 2010 95:2022-30. [PubMed:20801903] [PMC:PMC2995559] Related Antibodies: LS-C40952.

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Proteins (6)
Over-Expression Lysate (3)
Recombinant (3)
CD1A (6)
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6His, N-terminus (1)
Fc, C-terminus (1)
GST (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (1)
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HEK 293 Cells
6His, N-terminus
33.22 kDa
200 µg/$368
CD1A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
37.17 kDa
20 µg/$150
CD1A Protein - Purified recombinant protein CD1A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.2 kDa
20 µg/$1,107
CD1A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.17 kDa
100 µg/$494
CD1A Protein
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HEK 293 Cells
Fc, C-terminus
57 kDa
20 µg/$1,107
CD1A Protein - 12.5% SDS-PAGE of human CD1A stained with Coomassie Blue
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Wheat Germ Extract
GST
59.95 kDa
2 µg/$439
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).