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CD276 / B7-H3

CD276 molecule

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Gene Name: CD276 molecule
Synonyms: CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2
Target Sequences: NM_025240 NP_079516.1 Q5ZPR3

Publications (3)

1
B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome. Ingebrigtsen VA, Boye K, Nesland JM, Nesbakken A, Flatmark K, Fodstad Ø. BMC cancer. 2014 14:602. (Flo; Human) [Full Text Article] [PubMed:25139714] [PMC:PMC4148536]
2
B7-H3 promotes the proliferation, migration and invasiveness of cervical cancer cells and is an indicator of poor prognosis. Li Y, Zhang J, Han S, Qian Q, Chen Q, Liu L, Zhang Y. Oncology reports. 2017 August;38:1043-1050. [Full Text Article] [PubMed:28627681]
3
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma. Alyssa Noll, Carrie Myers, Matthew C Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E S Leary, Bonnie L Cole, Evangeline R Jackson, Matthew D Dun, Jessica B Foster, Myron K Evans, Siobhan S Pattwell, James M Olson, Nicholas A Vitanza. Neoplasia (New York, N.Y.). 2023 September;43:100921. [Full Text Article] [PubMed:37603953] [PMC:PMC10565710] Related Antibodies: LS-C743430.

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ELISA Kits (8)
Sandwich (7)
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CD276 / B7-H3 (8)
Human (6)
Mouse (1)
Rat (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (6)
No (7)
Yes (1)
Cell Culture Supernatants (2)
Cell Lysates (1)
Plasma (8)
Serum (8)
Tissue Homogenates (3)
Urine (1)
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$897
CD276 / B7-H3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
CD276 / B7-H3 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).