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CD27L / CD70

CD70 molecule

CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Gene Name: CD70 molecule
Family/Subfamily: TNF , not assigned-TNF
Synonyms: CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 molecule, TNFSF7
Target Sequences: NM_001252 NP_001243.1 P32970

Publications (3)

1
Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+<sup> T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma. Yang ZZ, Kim HJ, Villasboas JC, Price-Troska T, Jalali S, Wu H, Luchtel RA, Polley MC, Novak AJ, Ansell SM. Cell reports. 2019 February;26:2178-2193. [Full Text Article] [PubMed:30784598] [PMC:PMC6402596] Related Antibodies: LS-A8809.
2
CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis. Tessa Dhaeze, Laurence Tremblay, Catherine Lachance, Evelyn Peelen, Stephanie Zandee, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Xavier Ayrignac, Rose-Marie Rébillard, Josée Poirier, Boaz Lahav, Pierre Duquette, Marc Girard, Robert Moumdjian, Alain Bouthillier, Catherine Larochelle, Alexandre Prat. Cellular & molecular immunology. 2019 Jul;16:652-665. [Full Text Article] [PubMed:30635649] [PMC:PMC6804668]
3
CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity. Tim Sauer, Kathan Parikh, Sandhya Sharma, Bilal Omer, David Sedloev, Qian Chen, Linus Angenendt, Christoph Schliemann, Michael Schmitt, Carsten Müller-Tidow, Stephen Gottschalk, Cliona M Rooney. Blood. 2021 July;138:318-330. [Full Text Article] [PubMed:34323938] [PMC:PMC8323977] Related Antibodies: LS-A8809.

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CD27L / CD70 ELISA Kit
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96-Well Microplate
Human
0.3 - 70 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
CD27L / CD70 ELISA Kit
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96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
CD27L / CD70 ELISA Kit
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Custom
96-Well Microplate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$823
CD27L / CD70 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CD27L / CD70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CD27L / CD70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD27L / CD70 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CD27L / CD70 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
CD27L / CD70 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
10 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$897
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).