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CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Gene Name: | CD70 molecule |
Family/Subfamily: | TNF , not assigned-TNF |
Synonyms: | CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 molecule, TNFSF7 |
Target Sequences: | NM_001252 NP_001243.1 P32970 |
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