CD40

CD40 molecule, TNF receptor superfamily member 5

CD40 is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Products

Antibodies (243)

Type

Primary (243)

Target

CD40 (243)

Reactivity

Human (159)

Mouse (83)

Rat (25)

Bovine (3)

Chimpanzee (3)

Cynomolgus (3)

Dog (4)

Gerbil (1)

Marmoset (2)

Monkey (9)

Pig (4)

Rabbit (4)

Rhesus monkey (1)

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Application

IHC (51)

IHC-Fr (11)

IHC-P (24)

WB (105)

Flo (111)

Activ (1)

Block (3)

ELISA (69)

Func (13)

ICC (8)

IF (14)

IHC-IF (1)

IP (31)

Peptide-ELISA (4)

PMA (2)

SPR (2)

Stim (1)

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Host

rabbit (98)

mouse (94)

goat (1)

hamster (1)

human (1)

rat (48)

Product Group

IHCPlus (4)

PathPlus Neuro (2)

Isotype

IgG (51)

IgG,k (2)

IgG,l (1)

IgG1 (44)

IgG1,k (14)

IgG2a (32)

IgG2a,k (27)

IgG2b (7)

IgG2b,k (5)

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IgM,k (1)

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monoclonal mc (142)

polyclonal pc (95)

recombinant monoclonal rmc (6)

Clone

01 (1)

11 (2)

1C10 (7)

1G1 (1)

3/23 (6)

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A54 scFv (1)

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C40/2383 (2)

CDLA40-1 (2)

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FGK4.5/FGK45 (20)

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G28.5 (10)

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HI40a (5)

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IL-A156 (3)

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Biotin Conjugated (19)

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SPRD Conjugated (1)

Unconjugated (124)

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Epitope

aa21-166 (24)

aa24-193 (8)

aa247-276 (8)

aa26-187 (8)

aa26-193 (8)

N-Terminus (7)

Extracellular Domain (5)

aa181-207 (5)

aa33-62 (5)

CD40 (4)

aa35-84 (4)

aa71-120 (4)

pThr254 (2)

190-270 aa (1)

200-280 aa, C-terminal (1)

C-Terminus (1)

Cytoplasmic Domain (1)

Gln259 (1)

aa20-37 (1)

aa22-36 (1)

aa228-277 (1)

aa258-277 (1)

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Publications

No (241)

Yes (2)

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PathPlus™ CD40 Antibody (clone LOB7/6) LS-B2596

Neuroscience

(5.0) Rating

(1) Publication(s)

Antibody:

CD40 Mouse anti-Human Monoclonal (LOB7/6) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-Fr, IHC-P, IP

Format:

Unconjugated

Price:

50 µg/$460

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PathPlus™ CD40 Antibody (clone HB14) LS-B1956

Neuroscience

(5.0) Rating

(2) Publication(s)

Antibody:

CD40 Mouse anti-Human Monoclonal (HB14) Antibody

Reactivity:

Human, Monkey

Applications:

Flo, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ CD40 Antibody LS-B9072

(4.0) Rating

Antibody:

CD40 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

Flo, ICC, IHC, IHC-Fr, IHC-P, IP

Format:

Unconjugated

Price:

100 µg/$485

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CD40 Antibody (Extracellular Domain) LS-C123011

Antibody:

CD40 Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody

Reactivity:

Mouse

Applications:

ELISA, Flo, Func, IHC, IHC-Fr

Format:

Unconjugated

Price:

500 µg/$968

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CD40 Antibody (aa21-166, clone OTI1F12) LS-C340328

Antibody:

CD40 Mouse anti-Human Monoclonal (aa21-166) (OTI1F12) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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CD40 Antibody (aa258-277) LS-C63147

Antibody:

CD40 Rabbit anti-Human Polyclonal (aa258-277) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$370; 200 µg/$595

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CD40 Antibody (clone G28.5, Azide-free, Low Endotoxin) LS-C812204

Antibody:

CD40 Mouse anti-Human Monoclonal (Azide-free, Low Endotoxin) (G28.5) Antibody

Reactivity:

Human

Applications:

Flo, Func, Stim

Format:

Unconjugated, Azide-free, Low Endotoxin

Price:

50 µg/$258; 500 µg/$408; 1 mg/$508

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CD40 Antibody (clone FGK45) LS-C344785

Antibody:

CD40 Rat anti-Mouse Monoclonal (FGK45) Antibody

Reactivity:

Mouse

Applications:

Flo, Func

Format:

Unconjugated

Price:

100 µg/$316; 500 µg/$400

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IHC-plus™ CD40 Antibody LS-B16825

(4.0) Rating

Antibody:

CD40 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ CD40 Antibody (clone EA-5, Azide-free) LS-B11317

(4.0) Rating

Antibody:

CD40 Mouse anti-Human Monoclonal (Azide-free) (EA-5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, Func, IHC, IHC-P

Format:

Unconjugated, Azide-free

Price:

50 µg/$460

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CD40 Antibody (clone 1G1) LS-C196861

Antibody:

CD40 Mouse anti-Human Monoclonal (1G1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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CD40 Antibody (C-Terminus) LS-C351964

Antibody:

CD40 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Dog, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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CD40 Antibody (Extracellular Domain, clone 3/23) LS-C43310

Antibody:

CD40 Rat anti-Mouse Monoclonal (Extracellular Domain) (3/23) Antibody

Reactivity:

Mouse

Applications:

ELISA, Flo, IF, IHC, IHC-Fr

Format:

Unconjugated

Price:

0.1 mg/$385; 0.25 mg/$471

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CD40 Antibody (Cytoplasmic Domain) LS-C190624

Antibody:

CD40 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody

Reactivity:

Mouse, Dog, Rat, Gerbil, Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$558

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CD40 Antibody (N-Terminus, Magnetic beads) LS-C171685

Antibody:

CD40 Rabbit anti-Mouse Polyclonal (N-Terminus) (Magnetic beads) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

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CD40 Antibody LS-C5112

Antibody:

CD40 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$596

Select

CD40 Antibody (aa21-166, clone OTI8B8) LS-C340324

Antibody:

CD40 Mouse anti-Human Monoclonal (aa21-166) (OTI8B8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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CD40 Antibody (CD40, clone 5D12) LS-C777451

Antibody:

CD40 Rabbit anti-Human Recombinant Monoclonal (CD40) (5D12) Antibody

Reactivity:

Human, Cynomolgus, Marmoset

Applications:

Block, ELISA, Flo, IHC, IP, SPR

Format:

Unconjugated

Price:

0.2 mg/$540

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CD40 Antibody (clone BE-1) LS-C134424

Antibody:

CD40 Mouse anti-Human Monoclonal (BE-1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, Func, IP

Format:

Unconjugated

Price:

100 µg/$411

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CD40 Antibody (clone BE-1, Biotin) LS-C134425

Antibody:

CD40 Mouse anti-Human Monoclonal (Biotin) (BE-1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, Func, IP

Format:

Biotin Conjugated

Price:

100 µg/$446

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

CD40 Antibody (clone 3/23, PE) LS-C62612

Antibody:

CD40 Rat anti-Mouse Monoclonal (PE) (3/23) Antibody

Reactivity:

Mouse

Applications:

Flo, IHC, IHC-Fr

Format:

PE Conjugated

Price:

50 µg/$340; 300 µg/$900

Select

CD40 Antibody (clone EA-5) LS-C134639

Antibody:

CD40 Mouse anti-Human Monoclonal (EA-5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, Func

Format:

Unconjugated

Price:

100 µg/$411

Select

CD40 Antibody (clone EA-5, Biotin) LS-C134640

Antibody:

CD40 Mouse anti-Human Monoclonal (Biotin) (EA-5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, Func

Format:

Biotin Conjugated

Price:

100 µg/$446

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

CD40 Antibody (clone 9G10) LS-C758784

Antibody:

CD40 Mouse anti-Human Monoclonal (9G10) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$541

Select

CD40 Antibody (Biotin) LS-C35579

Antibody:

CD40 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IP

Format:

Biotin Conjugated

Price:

100 µg/$626

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