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CD44

CD44 molecule (Indian blood group)

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Gene Name:	CD44 molecule (Indian blood group)
Synonyms:	CD44, CDW44, CD44 antigen, Cell surface glycoprotein CD44, CSPG8, ECMR-III, Epican, HUTCH-I, LHR, MDU2, MC56, MIC4, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, PGP-I, Pgp1, Phagocytic glycoprotein I, MDU3, CD44R, HCELL, Heparan sulfate proteoglycan
Target Sequences:	NM_000610 NP_000601.3 P16070

Publications (14)

Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5774-9. (IHC) [PubMed:18391223] [PMC:PMC2311360]

Peritoneal tumor carcinomatosis: pharmacological targeting with hyaluronan-based bioconjugates overcomes therapeutic indications of current drugs. Montagner IM, Merlo A, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. PloS one. 2014 9:e112240. (Flo; Human) [Full Text Article] [PubMed:25383653] [PMC:PMC4226476]

Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. Montagner IM, Merlo A, Carpanese D, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. Oncoscience. 2015 2:373-81. (Flo; Human) [PubMed:26097871] [PMC:PMC4468323]

Osteopontin inhibits HIF-2a mRNA expression in osteoarthritic chondrocytes. Cheng C, Zhang FJ, Tian J, Tu M, Xiong YL, Luo W, Li YS, Song BB, Gao SG, Lei GH. Experimental and therapeutic medicine. 2015 9:2415-2419. (Block; Human) [Full Text Article] [PubMed:26136997] [PMC:PMC4473661]

Auramine O, an incense smoke ingredient, promotes lung cancer malignancy. Tung JC, Huang WC, Yang JC, Chen GY, Fan CC, Chien YC, Lin PS, Candice Lung SC, Chang WC. Environmental toxicology. 2017 32:2379-2391. (IP; Human) [Full Text Article] [PubMed:28722353] [PMC:PMC5655719] Related Antibodies: LS-C44932.

Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice. Barnes L, Saurat JH, Kaya G. PloS one. 2017 January;12:e0169452. (Mouse) [Full Text Article] [PubMed:28099467] [PMC:PMC5242443] Related Antibodies: LS-C44149.

Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells. Scutera S, Salvi V, Lorenzi L, Piersigilli G, Lonardi S, Alotto D, Casarin S, Castagnoli C, Dander E, D'Amico G, Sozzani S, Musso T. Frontiers in immunology. 2018 June;9:1207. (Human) [Full Text Article] [PubMed:29910810] [PMC:PMC5992779]

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages. Hosoon Choi, Ryang Hwa Lee, Nikolay Bazhanov, Joo Youn Oh, Darwin J Prockop. Blood. 2011 July;118:330-8. [Full Text Article] [PubMed:21551236] [PMC:PMC3138686] Related Antibodies: LS-C34583.

Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701] Related Antibodies: LS-B5508.

A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Feng Liu, Hongyao Xu, He Huang. Stem cell research & therapy. 2019 July;10:201. [Full Text Article] [PubMed:31287023] [PMC:PMC6615105] Related Antibodies: LS-C13434.

CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. Katrin Kleinmanns, Katharina Bischof, Shamundeeswari Anandan, Mihaela Popa, Lars A Akslen, Vibeke Fosse, Ida Tveit Karlsen, Bjørn T Gjertsen, Line Bjørge, Emmet McCormack. EBioMedicine. 2020 Jun;56:102782. [Full Text Article] [PubMed:32454401] [PMC:PMC7248428] Related Antibodies: LS-C46494.

New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis. Daniel F Lusche, Deborah J Wessels, Ryan J Reis, Cristopher C Forrest, Alexis R Thumann, David R Soll. PloS one. 2021 Apr;16:e0250175. [Full Text Article] [PubMed:33891595] [PMC:PMC8064539]

Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1ß Production. Jeong-Hoon Jang, Do-Hee Kim, Jae Min Lim, Joon Won Lee, Su Jin Jeong, Kwang Pyo Kim, Young-Joon Surh. Cancer research. 2020 March;80:1342-1356. [Full Text Article] [PubMed:31969374]

Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis. Qing Liu, Hao Zeng, Yuhao Yuan, Zhiwei Wang, Ziyi Wu, Wei Luo. Genes & diseases. 2022 January;9:128-139. [Full Text Article] [PubMed:35005113] [PMC:PMC8720673]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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