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CD47

CD47 molecule

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Gene Name: CD47 molecule
Synonyms: CD47, CD47 antigen, CD47 molecule, Integrin associated protein, Integrin-associated protein, Leukocyte surface antigen CD47, MER6, Protein MER6, Rh-related antigen, OA3, CD47 glycoprotein, IAP
Target Sequences: NM_001777 NP_001768.1 Q08722

Publications (3)

1
CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K. Cancer medicine. 2015 4:1322-33. (IP; Human) [Full Text Article] [PubMed:26077800] [PMC:PMC4567017]
2
Expression of CD47 antigen in Reed-Sternberg cells as a new potential biomarker for classical Hodgkin lymphoma. B López-Pereira, A A Fernández-Velasco, I Fernández-Vega, D Corte-Torres, C Quirós, J A Villegas, P Palomo, S González, A P González, Á Payer, T Bernal, M A Moro-García, R Alonso-Arias, S Alonso-Álvarez, E Colado. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2020 May;22:782-785. [Full Text Article] [PubMed:31359339]
3
Checkpoint CD47 expression in classical Hodgkin lymphoma. Alex Reza Gholiha, Peter Hollander, Liza Löf, Ingrid Glimelius, Gustaf Hedstrom, Daniel Molin, Henrik Hjalgrim, Karin E Smedby, Jamileh Hashemi, Rose-Marie Amini, Gunilla Enblad. British journal of haematology. 2022 June;197:580-589. [Full Text Article] [PubMed:35301709] [PMC:PMC9310712]

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CD47 (13)
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CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$748
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$624
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$901
CD47 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$669
CD47 ELISA Kit
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Custom
96-Well Strip Plate
Pig
1 Plate/$669
CD47 ELISA Kit
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Custom
96-Well Strip Plate
Rat
1 Plate/$669
CD47 ELISA Kit
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Custom
96-Well Strip Plate
Human
1 Plate/$669
CD47 ELISA Kit
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Custom
96-Well Strip Plate
Bovine
1 Plate/$669
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CD47 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
CD47 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$897
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).