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Vector Laboratories, Inc.
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Newark, CA 94560
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CD63

CD63 molecule

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

Gene Name: CD63 molecule
Family/Subfamily: Tetraspan , not assigned-Tetraspan
Synonyms: CD63, CD63 molecule, LAMP-3, ME491, Granulophysin, MLA1, Tetraspanin-30, Tspan-30, CD63 antigen, OMA81H, TSPAN30
Target Sequences: NM_001780 NP_001771.1 P08962

Publications (8)

1
Down-regulation of CD9 expression and its correlation to tumor progression in B lymphomas. Yoon SO, Zhang X, Freedman AS, Zahrieh D, Lossos IS, Li L, Choi YS. The American journal of pathology. 2010 177:377-86. [PubMed:20566742] [PMC:PMC2893680]
2
Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake. Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H. Communications biology. 2019 October;2: [Full Text Article] [PubMed:31646189] [PMC:PMC6802217]
3
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1. Lu Song, Xinran Tian, Randy Schekman. The Journal of cell biology. 2021 September;220: [Full Text Article] [PubMed:34309628] [PMC:PMC8313409] Related Antibodies: LS-C179520.
4
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease. Sandra Anne Banack, Rachael Anne Dunlop, Paul Alan Cox. Open biology. 2020 Jun;10:200116. [Full Text Article] [PubMed:32574550] [PMC:PMC7333885]
5
CD63 and C3AR1: The Potential Molecular Targets in the Progression of Septic Shock. Ning Yu, Xuefang Liu, Dandan Shi, Long Bai, Tianfu Niu, Ya Liu. International journal of general medicine. 2022 January;15:711-728. [Full Text Article] [PubMed:35082520] [PMC:PMC8784317]
6
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Akira Sobue, Norimichi Ito, Taku Nagai, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito, Kiyofumi Yamada. Glia. 2018 May;66:1034-1052. [Full Text Article] [PubMed:29380419] Related Antibodies: LS-C204227.
7
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Ayan Mohamud Yusuf, Nina Hagemann, Xiaoni Zhang, Maria Zafar, Tanja Hussner, Carolin Bromkamp, Carlotta Martiny, Tobias Tertel, Verena Börger, Fabian Schumacher, Fiorella A Solari, Mike Hasenberg, Christoph Kleinschnitz, Thorsten R Doeppner, Burkhard Kleuser, Albert Sickmann, Matthias Gunzer, Bernd Giebel, Richard Kolesnick, Erich Gulbins, Dirk M Hermann. Basic research in cardiology. 2022 December;117:43. [Full Text Article] [PubMed:36038749] [PMC:PMC9424180] Related Antibodies: LS-C204227.
8
Effects of pramipexole treatment on the α-synuclein content in serum exosomes of Parkinson's disease patients. Luo HT, Zhang JP, Miao F. Experimental and therapeutic medicine. 2016 12:1373-1376. (IHC, WB; Human) [Full Text Article] [PubMed:27588058] [PMC:PMC4998109] Related Antibodies: LS-C387289.
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ELISA Kits (16)
Custom (1)
Sandwich (13)
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CD63 (16)
Human (6)
Mouse (3)
Rat (1)
Chicken (1)
Guinea pig (1)
Porcine (1)
Rabbit (2)
12 x 8-Well Microstrips (1)
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96-Well Strip Plate (14)
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Cell Culture Supernatants (2)
Cell Lysates (4)
Plasma (11)
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CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$818
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$798
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD63 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CD63 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
13.7 - 10000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD63 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CD63 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$750
CD63 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CD63 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CD63 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).