CDK12 / CRKRS

cyclin-dependent kinase 12

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

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Products

ELISA Kits (5)

Type

Custom (1)

Sandwich (4)

Target

CDK12 / CRKRS (5)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Product Group

Alzheimer's Disease (5)

Format

96-Well Strip Plate (5)

Publications

No (5)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (1)

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Human CDK12 / CRKRS (Sandwich ELISA) ELISA Kit - LS-F35287

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$579

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Human CDK12 / CRKRS (Sandwich ELISA) ELISA Kit - LS-F13113

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat CDK12 / CRKRS (Sandwich ELISA) ELISA Kit - LS-F20086

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse CDK12 / CRKRS (Sandwich ELISA) ELISA Kit - LS-F20087

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Bovine CDK12 / CRKRS (Custom ELISA) ELISA Kit - LS-F20088

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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