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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

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Customer Service: (800) 227-6666 / (650) 697-3600


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CDKN1B / p27 Kip1

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms: CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Target Sequences: NM_004064 NP_004055.1 P46527

Publications (6)

1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB) [PubMed:19451650] [PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8. [PubMed:22139837] [PMC:PMC3265888]
3
Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremner. The Journal of thoracic and cardiovascular surgery. 2013 February;145:531-8. [Full Text Article] [PubMed:23142123] Related Antibodies: LS-C335975.
4
Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells. Jun-Yan Cai, Tong-Tong Xu, Ye Wang, Jing-Jian Chang, Jian Li, Xiao-Yang Chen, Xi Chen, Yi-Fei Yin, Xue-Jun Ni. International journal of oncology. 2018 Dec;53:2758-2768. [Full Text Article] [PubMed:30272277] Related Antibodies: LS-C17115.
5
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C389941.
6
A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-ß2 signaling. Chandrani Mondal, Majo J Gacha-Garay, Kathryn A Larkin, Rebecca C Adikes, Julie S Di Martino, Chen-Chi Chien, Madison Fraser, Ireti Eni-Aganga, Esperanza Agullo-Pascual, Katarzyna Cialowicz, Umut Ozbek, Alexandra Naba, Angelo Gaitas, Tian-Ming Fu, Srigokul Upadhyayula, Eric Betzig, David Q Matus, Benjamin L Martin, Jose Javier Bravo-Cordero. Cell reports. 2022 September;40:111358. [Full Text Article] [PubMed:36130489] [PMC:PMC9596226] Related Antibodies: LS-B3943.
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CDKN1B / p27 Kip1 (219)
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No (215)
Yes (4)
CDKN1B / p27 Kip1 Antibody - Anti-CDKN1B / p27 Kip1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ CDKN1B / p27 Kip1 Antibody (aa153-165) LS-B3943
(5.0) Rating
(1) Publication(s)
CDKN1B / p27 Kip1 Goat anti-Human Polyclonal (aa153-165) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CDKN1B / p27 Kip1 Antibody - Anti-CDKN1B / p27 Kip1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ CDKN1B / p27 Kip1 Antibody (clone 4B4-E6) LS-B5389
(4.0) Rating
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (4B4-E6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
CDKN1B / p27 Kip1 Antibody - Western blot of Phospho-p27 (T187) antibody
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CDKN1B / p27 Kip1 Antibody (130-210 aa) LS-C380895
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDKN1B / p27 Kip1 Antibody - Western blot analysis of lysates from HeLa cells treated with EGF or IFN-α, using p27 Kip1 (Phospho-Thr187) Antibody. The lane on the left is blocked with the phospho peptide.
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CDKN1B / p27 Kip1 Antibody (phospho-Thr187) LS-C117439
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDKN1B / p27 Kip1 Antibody - Western blot of Phospho-p27 (T198) antibody
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CDKN1B / p27 Kip1 Antibody (140-220 aa) LS-C380973
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human cervical cancer stained with p27 antibody (DCS-72.F6). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone DCS-72.F6) LS-C389941
(4.0) Rating
(1) Publication(s)
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human cervical cancer stained with p27 antibody (DCS-72.F6). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone DCS-72.F6, Ready-to-Use) LS-C389946
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Ready-to-Use) (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human cervical cancer stained with p27 antibody (DCS-72.F6). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone DCS-72.F6, Azide-free, BSA-free) LS-C389950
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Azide-free, BSA-free) (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Antibody - Immunohistochemistry of paraffin-embedded human breast carcinoma tissue.
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CDKN1B / p27 Kip1 Antibody (phospho-Thr187) LS-C335975
(4.0) Rating
(1) Publication(s)
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
IHC, WB
Unconjugated
100 µl/$431
CDKN1B / p27 Kip1 Antibody - The anti-Phospho-p27Kip1-T187antibody is used in Western blot to detect Phospho-p27Kip1-T187 in HL60 tissue lysate
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CDKN1B / p27 Kip1 Antibody (phospho-Thr187) LS-C96931
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Human
WB
Unconjugated
400 µl/$393
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CDKN1B / p27 Kip1 Antibody LS-C17115
(4.0) Rating
(1) Publication(s)
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$688
CDKN1B / p27 Kip1 Antibody - IHC of p27 on FFPE Breast Adenocarcinoma tissue.
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CDKN1B / p27 Kip1 Antibody (clone SX53G8) LS-C312129
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (SX53G8) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$332
CDKN1B / p27 Kip1 Antibody - Immunohistochemical analysis of p27 Kip1 (pT187) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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CDKN1B / p27 Kip1 Antibody (phospho-Thr187) LS-C354630
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Mouse, Dog, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
CDKN1B / p27 Kip1 Antibody - Immunohistochemical analysis of p27 Kip1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CDKN1B / p27 Kip1 Antibody (C-Terminus) LS-C351994
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
CDKN1B / p27 Kip1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PathPlus™ CDKN1B / p27 Kip1 Antibody LS-B16000
Cancer Pathology
Cancer
(5.0) Rating
CDKN1B / p27 Kip1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$460
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with p27Kip1 antibody (KIP1/769). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone KIP1/769) LS-C389970
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with p27Kip1 antibody (KIP1/769). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone KIP1/769, Ready-to-Use) LS-C389973
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Ready-to-Use) (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with p27Kip1 antibody (KIP1/769). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone KIP1/769, Azide-free, BSA-free) LS-C389982
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Antibody - IHC testing of FFPE human prostate cancer and p27Kip1 antibody (clone KIP27-1). This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDKN1B / p27 Kip1 Antibody (clone KIP27-1) LS-C391835
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Antibody - IHC testing of FFPE human prostate cancer and p27Kip1 antibody (clone KIP27-1). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CDKN1B / p27 Kip1 Antibody (clone KIP27-1, Azide-free, BSA-free) LS-C391842
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Antibody - IHC testing of FFPE human prostate cancer and p27Kip1 antibody (clone KIP27-1). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CDKN1B / p27 Kip1 Antibody (clone KIP27-1, Ready-to-Use) LS-C391845
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Ready-to-Use) (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Antibody - Western blot analysis of lysates from HeLa cells, HepG2 cells and COLO cells, using p27 Kip1 (Phospho-Thr198) Antibody. The lane on the right is blocked with the phospho peptide.
Select
CDKN1B / p27 Kip1 Antibody (phospho-Thr198) LS-C199369
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr198) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
CDKN1B / p27 Kip1 Antibody (aa1-198) LS-C123946
CDKN1B / p27 Kip1 Rat anti-Human Monoclonal (aa1-198) Antibody
Mouse, Rat, Human
IHC
Unconjugated
100 µg/$896
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with p27 antibody (DCS-72.F6 + KIP1/769). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CDKN1B / p27 Kip1 Antibody (clone DCS-72.F6 + KIP1/769, Azide-free, BSA-free) LS-C389955
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Azide-free, BSA-free) (DCS-72.F6 + KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Antibody - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with p27 antibody (SPM348). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CDKN1B / p27 Kip1 Antibody (clone SPM348) LS-C392201
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (SPM348) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
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