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CDKN1B / p27 Kip1

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms: CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Target Sequences: NM_004064 NP_004055.1 P46527

Publications (6)

1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB) [PubMed:19451650] [PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8. [PubMed:22139837] [PMC:PMC3265888]
3
Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremner. The Journal of thoracic and cardiovascular surgery. 2013 February;145:531-8. [Full Text Article] [PubMed:23142123] Related Antibodies: LS-C335975.
4
Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells. Jun-Yan Cai, Tong-Tong Xu, Ye Wang, Jing-Jian Chang, Jian Li, Xiao-Yang Chen, Xi Chen, Yi-Fei Yin, Xue-Jun Ni. International journal of oncology. 2018 Dec;53:2758-2768. [Full Text Article] [PubMed:30272277] Related Antibodies: LS-C17115.
5
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C389941.
6
A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-ß2 signaling. Chandrani Mondal, Majo J Gacha-Garay, Kathryn A Larkin, Rebecca C Adikes, Julie S Di Martino, Chen-Chi Chien, Madison Fraser, Ireti Eni-Aganga, Esperanza Agullo-Pascual, Katarzyna Cialowicz, Umut Ozbek, Alexandra Naba, Angelo Gaitas, Tian-Ming Fu, Srigokul Upadhyayula, Eric Betzig, David Q Matus, Benjamin L Martin, Jose Javier Bravo-Cordero. Cell reports. 2022 September;40:111358. [Full Text Article] [PubMed:36130489] [PMC:PMC9596226] Related Antibodies: LS-B3943.
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ELISA Kits (10)
Cell-Based (1)
Cell-Based Phosphorylation (3)
Sandwich (5)
Sandwich CLIA (1)
CDKN1B / p27 Kip1 (10)
Human (7)
Mouse (5)
Rat (2)
12 x 8-Well Microstrips (1)
96-Well Microplate (7)
96-Well Strip Plate (2)
No (10)
Adherent Cell Cultures (4)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (5)
Serum (5)
Tissue Homogenates (3)
CDKN1B / p27 Kip1 ELISA Kit
Select
Human CDKN1B / p27 Kip1 (Sandwich ELISA) ELISA Kit - LS-F466
Sandwich
96-Well Microplate
Human
0.041 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
CDKN1B / p27 Kip1 ELISA Kit
Select
Human CDKN1B / p27 Kip1 (Cell-Based ELISA) ELISA Kit - LS-F2203
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
CDKN1B / p27 Kip1 ELISA Kit
Select
Mouse/Human/Rat Phospho-CDKN1B / p27 Kip1 (Ser10) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1585
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CDKN1B / p27 Kip1 ELISA Kit
Select
Mouse/Human/Rat Phospho-CDKN1B / p27 Kip1 (Thr187) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1586
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CDKN1B / p27 Kip1 ELISA Kit
Select
Human Phospho-CDKN1B / p27 Kip1 (Thr198) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1367
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CDKN1B / p27 Kip1 ELISA Kit
Select
Mouse CDKN1B / p27 Kip1 (CLIA) ELISA Kit - LS-F30624
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
3.125 - 200 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CDKN1B / p27 Kip1 ELISA Kit
Select
Human CDKN1B / p27 Kip1 (Sandwich ELISA) ELISA Kit - LS-F56306
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CDKN1B / p27 Kip1 ELISA Kit
Select
Human CDKN1B / p27 Kip1 (Sandwich ELISA) ELISA Kit - LS-F74141
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
CDKN1B / p27 Kip1 ELISA Kit
Select
Mouse CDKN1B / p27 Kip1 (Sandwich ELISA) ELISA Kit - LS-F24161
Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CDKN1B / p27 Kip1 ELISA Kit
Select
Mouse CDKN1B / p27 Kip1 (Sandwich ELISA) ELISA Kit - LS-F32870
Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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