CDKN2A

cyclin-dependent kinase inhibitor 2A

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 6 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.

☰ Filters

Products

Proteins (3)

Type

Over-Expression Lysate (1)

Recombinant (2)

Target

CDKN2A (3)

Publications

No (3)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (1)

Species

Human (3)

Source

293T Cells (1)

E. coli (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

Select

Human CDKN2A Protein (Recombinant His, N-Terminal) (aa8-156) - LS-G12847

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

19.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

Select

Human CDKN2A Protein (Recombinant) - LS-G67

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

16.5 kDa

Price:

5 µg/$268; 20 µg/$349

Select

Human CDKN2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75348

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.4 kDa

Price:

20 µg/$150

Viewing 1-3 of 3 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.