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CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
|Gene Name:||cadherin, EGF LAG seven-pass G-type receptor 2|
|Family/Subfamily:||GPCR , Orphan-U|
|Synonyms:||CELSR2, Cadherin family member 10, CDHF10, EGF-like-domain, multiple 2, Epidermal growth factor-like 2, EGF-like protein 2, EGFL2, Flamingo homolog 3, KIAA0279, Megf3, Flamingo1|
|Target Sequences:||NM_001408 NP_001399.1 Q9HCU4|
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