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CSF1 / MCSF
colony stimulating factor 1 (macrophage)
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
| Gene Name: | colony stimulating factor 1 (macrophage) |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | CSF1, CSF-1, MCSF, M-CSF, Lanimostim, CSFM |
| Target Sequences: | NM_000757 NP_000748.3 P09603 |
Publications (1)
1
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma. Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liangzhan Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yongxu Jia, Dora Lai-Wan Kwong, NgarWoon Kam, Xin-Yuan Guan. Theranostics. 2020 October;10:11535-11548. [Full Text Article]
[PubMed:33052231]
[PMC:PMC7546008]
Related Antibodies: LS-C104656.
☰ Filters
Products
Proteins
(53)
Type
Over-Expression Lysate
(10)
Recombinant
(42)
Target
CSF1 / MCSF
(53)
Format
Animal-free
(3)
Publications
No
(53)
Tag
6His, C-terminus
(5)
6His, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(1)
His, C-Terminal
(1)
His, N-Terminal
(1)
His-GST-S
(1)
His-T7
(1)
Myc-DDK (Flag)
(14)
Species
Human
(28)
Mouse
(14)
Rat
(5)
Source
293T Cells
(5)
CHO Cells
(3)
E. coli
(17)
HEK 293 Cells
(13)
Human
(1)
Human Cells
(4)
Mammalian Cells
(5)
Wheat Germ Extract
(2)
Purification
Purified
(20)
Low Endotoxin Level
Low endotoxin level
(28)
Biologically Active
Biologically active
(24)
Animal-free
Animal-free
(3)
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
35-44 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 179 amino acid recombinant protein has a predicted molecular mass of approximately 20.6 kD. The DTT-reduced and non-reduced protein migrate at approximately 25- 35 kD and 55-70 kD respectively by SDS-PAGE. The N-terminal contains a His9-(SGGG)2-IEGR-t
10 µg/$283; 25 µg/$344; 100 µg/$689; 500 µg/$1,595
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
32-40 kDa (SDS-PAGE)
5 µg/$278; 25 µg/$364
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
32-40 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
36.8 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$369
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
36.4 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.1 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
E. coli
None
Biologically active
36.8 kDa
10 µg/$388; 100 µg/$1,277; 500 µg/$2,501
E. coli
None
Biologically active
52.0 kDa
10 µg/$388; 100 µg/$1,277; 500 µg/$2,501
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
29 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,107
E. coli
His-T7
23.6 kDa
50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
E. coli
His-GST-S
80.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
6His, N-terminus
60 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
28 kDa (SDS-PAGE)
100 µg/$711; 10 µg/$296; 1 mg/$2,653
Wheat Germ Extract
GST
86.5 kDa
10 µg/$479; 25 µg/$670
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product results
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