CTNNB1 / Beta Catenin

catenin (cadherin-associated protein), beta 1, 88kDa

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

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Products

Proteins (22)

Type

Over-Expression Lysate (8)

Recombinant (14)

Target

CTNNB1 / Beta Catenin (22)

Publications

No (22)

Tag

6His, N-terminus (1)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (2)

His (3)

His, N-Terminal (1)

His-GST (2)

Myc-DDK (Flag) (11)

Species

Human (15)

Mouse (2)

Rat (1)

Source

293T Cells (4)

Baculovirus (2)

E. coli (4)

HEK 293 Cells (7)

Sf9 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human CTNNB1 / Beta Catenin Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G136584

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

87.4 kDa

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human CTNNB1 / Beta Catenin Protein (Recombinant His) (aa439-675) - LS-G13249

Source:

E. coli

Tag:

His

Molecular Weight:

27.7 kDa

Price:

10 µg/$274; 50 µg/$397; 100 µg/$635; 200 µg/$792; 1 mg/$1,864; 500 µg/$1,419; 5 mg/$2,826; 2 mg/$2,047

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Mouse CTNNB1 / Beta Catenin Protein (Recombinant His) (aa508-762) - LS-G13254

Source:

E. coli

Tag:

His

Molecular Weight:

29.5 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74767

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$150

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Human CTNNB1 / Beta Catenin Protein (Recombinant GST, N-terminus) (Full Length) - LS-G22046

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

112.7 kD

Price:

100 µg/$420; 20 µg/$323

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Mouse CTNNB1 / Beta Catenin Protein (Recombinant His-GST) (Met1-Leu781) - LS-G98121

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

113 kDa

Price:

20 µg/$603

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Human CTNNB1 / Beta Catenin Protein (Recombinant GST, N-terminus) (aa682-781) - LS-G58257

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CTNNB1 / Beta Catenin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65062

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$1,107

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Human CTNNB1 / Beta Catenin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65063

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$1,107

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Human CTNNB1 / Beta Catenin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65066

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$1,107

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Rat CTNNB1 / Beta Catenin Protein (Recombinant His) (aa409-665) - LS-G13252

Source:

E. coli

Tag:

His

Molecular Weight:

29.3 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human CTNNB1 / Beta Catenin Protein (Recombinant GST) (Full Length) - LS-G28096

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

111.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74763

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$215

Select

Human CTNNB1 / Beta Catenin Protein (Recombinant His-GST) (Met1-Leu781) - LS-G97360

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

113 kDa

Price:

100 µg/$721

Select

Human CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74765

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$215

Select

Human CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74764

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

20 µg/$215

Select

CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118315

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

100 µg/$494

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CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119186

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

100 µg/$710

Select

CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119187

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

100 µg/$710

Select

Human CTNNB1 / Beta Catenin Protein (Recombinant DDK,C-terminus) - LS-G142332

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

85 kDa

Price:

20 µg/$677

Select

Human CTNNB1 / Beta Catenin Protein (Recombinant His, N-Terminal) - LS-G142384

Source:

Sf9 Cells

Tag:

His, N-Terminal

Molecular Weight:

85 kDa

Price:

20 µg/$677

Select

CTNNB1 / Beta Catenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123968

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.3 kDa

Price:

100 µg/$710

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