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Infectious Disease
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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CXCL1 / GRO Alpha
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.
| Gene Name: | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| Family/Subfamily: | Intercrine , Intercrine alpha |
| Synonyms: | CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1 |
| Target Sequences: | NM_001511 NP_001502.1 P09341 |
Publications (6)
1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human)
[Full Text Article]
[PubMed:25785838]
[PMC:PMC4364666]
Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat)
[Full Text Article]
[PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article]
[PubMed:30152858]
[PMC:PMC6240131]
☰ Filters
Products
Proteins
(35)
Type
Recombinant
(35)
Target
CXCL1 / GRO Alpha
(35)
Publications
No
(35)
Tag
6His, C-terminus
(5)
6His, N-terminus
(1)
GST
(2)
GST, N-terminus
(1)
His
(3)
His, N-Terminal
(2)
His-GST
(2)
His-MBP
(1)
His-T7
(1)
Species
Human
(15)
Mouse
(15)
Rat
(4)
Source
293F Cells
(1)
CHO Cells
(1)
E. coli
(25)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(16)
Low Endotoxin Level
Low endotoxin level
(16)
Biologically Active
Biologically active
(13)
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 73 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10 µg/$283; 25 µg/$355; 100 µg/$749; 500 µg/$1,828
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 25 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.8 kDa
5 µg/$268; 25 µg/$349
E. coli
None
Biologically active
7.9 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
7.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
7.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His-T7
11.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-GST
40.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His-GST
34.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-MBP
54.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
11.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His
11.6 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Wheat Germ Extract
GST
37.51 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
37.7 kDa
10 µg/$479; 25 µg/$670
CHO Cells
None
Less than 0.2 EU/µg protein (determined by LAL method).
5-7 kDa (SDS-PAGE)
5 µg/$253; 25 µg/$296; 1 mg/$1,513
293F Cells
His, N-Terminal
12kDa
10 µg/$315; 50 µg/$652; 200 µg/$1,228; 100 µg/$1,034; 1 mg/$2,469; 500 µg/$1,971; 5 mg/$4,551; 2 mg/$2,661
E. coli
None
Less than 0.01 ng/µg (determined by LAL method).
The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.4 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10 µg/$325; 25 µg/$459; 500 µg/$2,640
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.8 kDa
1 mg/$2,653; 20 µg/$364
E. coli
His, N-Terminal
7.8 kDa
50 µg/$419
E. coli
None
7.8 kDa
5 µg/$282; 25 µg/$370
E. coli
6His, C-terminus
10.6 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
8.6 kDa
50 µg/$453; 10 µg/$288; 1 mg/$2,837; 500 µg/$1,987
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of 35
product results
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