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CXCR3

chemokine (C-X-C motif) receptor 3

CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Gene Name: chemokine (C-X-C motif) receptor 3
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR3, C-x-c chemokine receptor 3, CD183 antigen, CKR-L2, CXCR-3, CMKAR3, CD182, CD183, Cxcr3a, GPR9, IP-10 receptor, IP10-R, Mig receptor, MigR, Mig-R, Chemokine (C-X-C) receptor 3, CXC-R3, Cxcr3b, G protein-coupled receptor 9, IP10 receptor
Target Sequences: NM_001504 NP_001495.1 P49682

Publications (6)

1
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. Denkert C, Loibl S, Noske A, Roller M, Mller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, von Trne C, Weichert W, Engels K, Solbach C, Schrader I, Dietel M, von Minckwitz G. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 28:105-13. (IHC-P; Human) [PubMed:19917869] Related Antibodies: LS-C6283.
2
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, Ku AW, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS. Nature communications. 2015 6:7458. (Block; Human) [Full Text Article] [PubMed:26109379] [PMC:PMC4605273] Related Antibodies: LS-C6283.
3
CXCR3 regulates CD4+ T cell cardiotropism in pressure overload-induced cardiac dysfunction. Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz M, Luster AD, Huggins GS, Alcaide P. JCI insight. 2019 April;4:pii: 125527. [Full Text Article] [PubMed:30779709] [PMC:PMC6483643] Related Antibodies: LS-B10183.
4
CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions. Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz. eLife. 2021 July;10: [Full Text Article] [PubMed:34328416] [PMC:PMC8360647] Related Antibodies: LS-C332293.
5
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model. Floriana Cremasco, Elena Menietti, Dario Speziale, Johannes Sam, Stefano Sammicheli, Marine Richard, Ahmet Varol, Christian Klein, Pablo Umana, Marina Bacac, Sara Colombetti, Mario Perro. PloS one. 2021 Jan;16:e0241091. [Full Text Article] [PubMed:33406104] [PMC:PMC7787458] Related Antibodies: LS-B10183.
6
Microparticle-Delivered Cxcl9 Prolongs Braf Inhibitor Efficacy in Melanoma. Gabriele Romano, Francesca Paradiso, Peng Li, Pooja Shukla, Lindsay N Barger, Olivia El Naggar, John P Miller, Roger J Liang, Timothy L Helms, Alexander J Lazar, Jennifer A Wargo, Francesca Taraballi, James C Costello, Lawrence N Kwong. Cancer immunology research. 2023 May;11:558-569. [Full Text Article] [PubMed:36820825] [PMC:PMC10159986] Related Antibodies: LS-B10183.
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Antibodies (65)
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CXCR3 Antibody - Anti-CXCR3 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CXCR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
CXCR3 Antibody - Anti-CXCR3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CXCR3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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CXCR3 Mouse anti-Human Monoclonal (2AR1) Antibody
Human
Flo, Func, IHC, Neut
Unconjugated
100 µg/$962
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CXCR3 Mouse anti-Human Monoclonal (CF) (2AR1) Antibody
Human
Flo
CF Conjugated
1 ml/$755
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CXCR3 Mouse anti-Human Monoclonal (PE) (2AR1) Antibody
Human
Flo
PE Conjugated
1 ml/$872
CXCR3 Antibody - Immunohistochemistry of paraffin-embedded human stomach cancer tissue using CXCR3 antibody.
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CXCR3 Rabbit anti-Human Polyclonal (aa289-368) Antibody
Mouse, Human
IHC-P, WB
Unconjugated
20 µl/$275; 100 µl/$389
CXCR3 Antibody - Anti-CXCR3 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CXCR3 Rabbit anti-Human Polyclonal (aa161-210) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CXCR3 Antibody - Western blot of CXCR3 in human pancreas cell lysate using CXCR3 Antibody at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
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CXCR3 Rabbit anti-Human Polyclonal (aa290-303) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$386
CXCR3 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CXCR3 Antibody - Immunohistochemistry of paraffin-embedded mouse heart using CXCR3 antibody at dilution of 1:100
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CXCR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
CXCR3 Antibody - Goat Anti-CXCR3 / GPR9 Antibody Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing membrane staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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CXCR3 Goat anti-Human Polyclonal (aa399-410) Antibody
Human, Monkey
IF, Peptide-ELISA
Unconjugated
100 µg/$503
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CXCR3 Mouse anti-Human Monoclonal (APC) (G025H7) Antibody
Human
Flo
APC Conjugated
20 Tests/$263; 100 Tests/$367; 200 Tests/$445
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CXCR3 Mouse anti-Human Monoclonal (PE) (G025H7) Antibody
Human
Flo
PE Conjugated
20 Tests/$261; 100 Tests/$346; 200 Tests/$415
CXCR3 Antibody - Immunohistochemistry Dilution at 1:1200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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CXCR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CXCR3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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CXCR3 Mouse anti-Human Monoclonal (5C10E6) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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CXCR3 Rabbit anti-Human Polyclonal (aa338-349) Antibody
Human
WB
Unconjugated
100 µg/$649
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CXCR3 Hamster-Armenian anti-Mouse Monoclonal (AF647) (CXCR3-173) Antibody
Mouse
Flo
AF647 Conjugated
50 Tests/$260; 100 Tests/$291; 200 Tests/$348
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CXCR3 Mouse anti-Human Monoclonal (5C10B3) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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CXCR3 Rabbit anti-Human Polyclonal (aa140-167) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CXCR3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$782
Viewing 1-25 of 96 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).