CXCR4

chemokine (C-X-C motif) receptor 4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

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Proteins (9)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (2)

Recombinant (6)

Target

CXCR4 (9)

Publications

No (9)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (8)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (4)

Supernatant (1)

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Human CXCR4 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Glu2-Ser352) - LS-G26866

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

42 kDa

Price:

200 µl/$283

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Human CXCR4 Protein (Recombinant GST) (Full Length) - LS-G31017

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.46 kDa

Price:

2 µg/$439

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Human CXCR4 Protein (Recombinant 6His, N-terminus) (aa1-352) - LS-G56001

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$1,293; 20 µg/$854

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Human CXCR4 Protein (Recombinant GST, N-terminus) (aa1-46) - LS-G60614

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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CXCR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100058

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

100 µg/$494

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Human CXCR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74886

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

20 µg/$150

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Human CXCR4 Protein (Recombinant GST, N-terminus) - LS-G146220

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

31.2kDa

Price:

20 µg/$330; 100 µg/$450

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Human CXCR4 Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa303-352) - LS-G56193

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CXCR4 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-352) - LS-G55999

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

100 µg/$1,293; 20 µg/$854

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