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DDC / DOPA Decarboxylase

dopa decarboxylase (aromatic L-amino acid decarboxylase)

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene Name: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Family/Subfamily: Carboxy-lyase , Not assigned-Other
Synonyms: DDC, AADC, DOPA decarboxylase
Target Sequences: NM_000790 NP_000781.1 P20711

Publications (2)

1
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages. Gratz MJ, Stavrou S, Kuhn C, Hofmann S, Hermelink K, Heidegger H, Hutter S, Mayr D, Mahner S, Jeschke U, Vattai A. Endocrine connections. 2018 May;7:727-738. (Human) [Full Text Article] [PubMed:29686031] [PMC:PMC5958746] Related Antibodies: LS-B10123.
2
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma. Yan Yan, Jiahao Pan, Yonghua Chen, Wei Xing, Qiang Li, Dongyin Wang, Xiaoshuang Zhou, Jingdun Xie, Changhong Miao, Yunfei Yuan, Weian Zeng, Dongtai Chen. Cancer communications (London, England). 2020 December;40:694-710. [Full Text Article] [PubMed:33017522] [PMC:PMC7743025]

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ELISA Kits (14)
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DDC / DOPA Decarboxylase (14)
Human (6)
Mouse (1)
Rat (1)
Chicken (1)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (11)
No (13)
Yes (1)
Cell Lysates (2)
Plasma (2)
Serum (2)
Tissue Homogenates (2)
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
DDC / DOPA Decarboxylase ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DDC / DOPA Decarboxylase ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DDC / DOPA Decarboxylase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
25 - 1600 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$792
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).