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DEFB1 / BD-1

defensin, beta 1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.

Gene Name: defensin, beta 1
Synonyms: DEFB1, BD1, Beta-defensin 1, BD-1, Beta Defensin 1, DEFB-1, DEFB101, Defensin, beta 1, Defensin beta, HBD-1, Beta-defensin-1, HBD1
Target Sequences: NM_005218 NP_005209.1 P60022

Publications (2)

1
Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. L A Ochoa-Ramírez, D S Becerra-Loaiza, S P Díaz-Camacho, V F Muñoz-Estrada, E R Ríos-Burgueño, E Prado-Montes de Oca, H Rangel-Villalobos, J S Velarde-Félix. Clinical and experimental dermatology. 2019 April;44:277-282. [Full Text Article] [PubMed:29923320]
2
Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract. Becknell B, Spencer JD, Carpenter AR, Chen X, Singh A, Ploeger S, Kline J, Ellsworth P, Li B, Proksch E, Schwaderer AL, Hains DS, Justice SS, McHugh KM. PloS one. 2013 8:e77714. [Full Text Article] [PubMed:24204930] [PMC:PMC3804605] Related Antibodies: LS-C20902.

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (2)
Recombinant (16)
DEFB1 / BD-1 (18)
No (18)
6His-SUMO, N-terminus (1)
GST (1)
His (2)
His-GST (2)
His-S (1)
Myc-DDK (Flag) (3)
Bovine (1)
Human (11)
Mouse (3)
Pig (1)
Rat (1)
293T Cells (1)
E. coli (14)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (7)
Biologically active (6)
DEFB1 / BD-1 Protein - The ED50 was determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/mL.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~4.2 kDa
20 µg/$319; 100 µg/$746; 1 mg/$2,551
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
3.9 kDa
5 µg/$268; 20 µg/$349
DEFB1 / BD-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
7.42 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
5.0 kDa
5 µg/$268; 20 µg/$349
DEFB1 / BD-1 Protein
Select
E. coli
None
Biologically active
5.1 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
DEFB1 / BD-1 Protein - Purified recombinant protein DEFB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
5 kDa
20 µg/$1,107
DEFB1 / BD-1 Protein - Recombinant Defensin Beta 1 By SDS-PAGE
Select
E. coli
His-S
10.9 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
Select
E. coli
His
6.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
DEFB1 / BD-1 Protein - Recombinant Defensin Beta 1 By SDS-PAGE
Select
E. coli
His
6.0 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
DEFB1 / BD-1 Protein - Recombinant Defensin Beta 1 By SDS-PAGE
Select
E. coli
His-GST
37.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
DEFB1 / BD-1 Protein - Recombinant  Defensin Beta 1 By SDS-PAGE
Select
E. coli
His-GST
36.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
DEFB1 / BD-1 Protein - 12.5% SDS-PAGE of human DEFB1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
33.22 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
5.1 kDa
1 mg/$2,941; 25 µg/$351
DEFB1 / BD-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
7.42 kDa
100 µg/$494
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
5.1 kDa
10 µg/$288; 50 µg/$436
DEFB1 / BD-1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
DEFB1 / BD-1 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~5 kDa
20 µg/$310; 500 µg/$1,813
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
5.07kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Viewing 1-18 of 18 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).