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DRD1 / Dopamine Receptor D1

dopamine receptor D1

DRD1, a Dopamine Receptor, mediates the effect of the neurotransmitter dopamine, an intermediate in the biosynthesis of noradrenaline and adrenaline. It is involved in the control of motor activity and cognitive memory. Downregulation of DRD1 leads to severe impairments in working memory and to locomotor hyperactivity, which are observed in diseases such as schizophrenia, Parkinson's disease, affective disorders, and attention deficit hyperactivity disorder. DRD1 enhances smooth muscle contraction and vasodilation in the heart. It also modulates sodium transport in the kidney and is involved in the pathogenesis of hypertension.

Gene Name: dopamine receptor D1
Family/Subfamily: GPCR , Dopamine
Synonyms: DRD1, D(1A) dopamine receptor, DRD1A, DADR, D1a receptor
Target Sequences: NM_000794 NP_000785.1 P21728

Publications (2)

1
Single-molecule imaging of the functional crosstalk between surface NMDA and dopamine D1 receptors. Laurent Ladepeche, Julien P Dupuis, Delphine Bouchet, Evelyne Doudnikoff, Luting Yang, Yohan Campagne, Erwan Bézard, Eric Hosy, Laurent Groc. Proceedings of the National Academy of Sciences of the United States of America. 2013 October;110:18005-10. [Full Text Article] [PubMed:24127604] [PMC:PMC3816474]
2
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma. Yan Yan, Jiahao Pan, Yonghua Chen, Wei Xing, Qiang Li, Dongyin Wang, Xiaoshuang Zhou, Jingdun Xie, Changhong Miao, Yunfei Yuan, Weian Zeng, Dongtai Chen. Cancer communications (London, England). 2020 December;40:694-710. [Full Text Article] [PubMed:33017522] [PMC:PMC7743025] Related Antibodies: LS-A44.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
DRD1 / Dopamine Receptor D1 (3)
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His, N-Terminal (1)
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DRD1 / Dopamine Receptor D1 Protein - Recombinant  Dopamine Receptor D1 By SDS-PAGE
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E. coli
His, N-Terminal
15.5 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
DRD1 / Dopamine Receptor D1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
49.1 kDa
100 µg/$494
DRD1 / Dopamine Receptor D1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
49.1 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).