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DSG3 / Desmoglein 3

desmoglein 3

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Gene Name: desmoglein 3
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: DSG3, Balding, BAL, Cadherin family member 6, CDHF6, Desmoglein 3, Pemphigus vulgaris antigen, Desmoglein-3, PVA
Target Sequences: NM_001944 NP_001935.2 P32926

Publications (9)

1
Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M. The British journal of dermatology. 2000 142:321-30. (WB) [PubMed:10730768]
2
Protection against pemphigus foliaceus by desmoglein 3 in neonates. Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M, Stanley JR. The New England journal of medicine. 2000 343:31-5. (ICC) [PubMed:10882766]
3
The fate of desmosomal proteins in apoptotic cells. Weiske J, Schneberg T, Schrder W, Hatzfeld M, Tauber R, Huber O. The Journal of biological chemistry. 2001 276:41175-81. (ICC, WB, IP) [PubMed:11500511]
4
Generation of monoclonal antibodies specific for desmoglein family members. Wahl JK. Hybridoma and hybridomics. 2002 21:37-44. (ICC, WB, IP) [PubMed:11991815]
5
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. Wu H, Stanley JR, Cotsarelis G. The Journal of investigative dermatology. 2003 120:1052-7. [PubMed:12787134]
6
Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. Lucchese A, Mittelman A, Lin MS, Kanduc D, Sinha AA. Journal of translational medicine. 2004 2:43. [PubMed:15588331] [PMC:PMC544587]
7
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK. Experimental dermatology. 2006 15:101-9. (WB, IP) [PubMed:16433681]
8
Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H. PloS one. 2010 5:e14211. (ICC) [PubMed:21151980] [PMC:PMC2997060]
9
Clinicopathological features of thymic carcinomas and the impact of histopathological agreement on prognostical studies. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2012 (IHC; Human) [PubMed:23086701]
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Antibodies (53)
Primary (53)
DSG3 / Desmoglein 3 (53)
Human (49)
Mouse (8)
Rat (5)
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IHC (7)
IHC-Fr (2)
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WB (44)
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ELISA (20)
ICC (5)
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Peptide-ELISA (1)
rabbit (40)
mouse (13)
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IHCPlus (2)
IgG (23)
IgG1 (7)
IgG1,k (6)
monoclonal mc (15)
polyclonal pc (38)
5G11 (3)
5H10 (7)
6G2C11 (1)
DSG3/1535 (2)
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Azide-free (4)
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aa858-999 (8)
aa8-36 (7)
aa854-903 (4)
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aa70-615 (1)
aa981-999 (1)
No (53)
DSG3 / Desmoglein 3 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (6G2C11) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
0.05 mg/$460
DSG3 / Desmoglein 3 Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using DSG3 Antibody at dilution of 1:100
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa70-615) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (5H10) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$386
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (Biotin) (5H10) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (DY650) (5H10) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (DY488) (5H10) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (DY550) (5H10) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
DSG3 / Desmoglein 3 Antibody - Western blot analysis of Desmoglein 3 expression in A431 (A); HeLa (B); Raw264.7 (C); PC12 (D) whole cell lysates.
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DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
DSG3 / Desmoglein 3 Antibody - Western Blot; Sample: Recombinant DSG3, Human.
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa858-999) Antibody
Pig, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
DSG3 / Desmoglein 3 Antibody - Western Blot; Sample: Recombinant DSG3, Human.
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa858-999) (APC) Antibody
Pig, Human
WB
APC Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Monoclonal (EP306) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$409; 0.5 ml/$615; 1 ml/$1,004
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Monoclonal (Ready-to-Use) (EP306) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$409; 7 ml/$509; 15 ml/$766
DSG3 / Desmoglein 3 Antibody - Western blot analysis of extracts of various cells.
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
DSG3 / Desmoglein 3 Antibody - DSG3 Antibody western blot of WiDr cell line lysates (35 ug/lane). The DSG3 antibody detected the DSG3 protein (arrow).
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa8-36) Antibody
Human
WB
Unconjugated
400 µl/$393
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (Concentrated) (5G11) Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated, Concentrated
1 ml/$638
DSG3 / Desmoglein 3 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa854-903) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
DSG3 / Desmoglein 3 Antibody - SDS-PAGE Analysis of Purified, BSA-Free Desmoglein 3 Antibody (clone 5H10). Confirmation of Integrity and Purity of the Antibody.
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (5H10) Antibody
Human
Flo, IF, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
DSG3 / Desmoglein 3 Antibody - SDS-PAGE Analysis of Purified, BSA-Free Desmoglein 3 Antibody (clone 5H10). Confirmation of Integrity and Purity of the Antibody.
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (5H10) Antibody
Human
Flo, IF, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
DSG3 / Desmoglein 3 Antibody - IHC testing of FFPE human skin with Desmoglein 3 antibody (clone 5G11). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (5G11) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
DSG3 / Desmoglein 3 Antibody - IHC testing of FFPE human skin with Desmoglein 3 antibody (clone 5G11). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (5G11) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
DSG3 / Desmoglein 3 Antibody - IHC testing of FFPE human skin with Desmoglein 3 antibody (clone DSG3/1535). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
Select
DSG3 / Desmoglein 3 Mouse anti-Human Monoclonal (DSG3/1535) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa8-36) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal (aa8-36) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
DSG3 / Desmoglein 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 53 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).