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DUSP4 / MKP2

dual specificity phosphatase 4

TYP / DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Gene Name: dual specificity phosphatase 4
Family/Subfamily: Protein Phosphatase , Dual specificity MKP
Synonyms: DUSP4, Dual specificity phosphatase 4, HVH2, MAPK phosphatase 2, MAP kinase phosphatase 2, MKP-2, MKP2, Typ 1, TYP, VH2, VH1 homologous phosphatase 2
Target Sequences: NM_001394 NP_001385.1 Q13115

☰ Filters
Products
Antibodies (42)
Primary (42)
DUSP4 / MKP2 (42)
Human (42)
Mouse (17)
Rat (10)
Bat (3)
Bovine (3)
Chimpanzee (6)
Dog (3)
Gibbon (6)
Guinea pig (3)
Hamster (3)
Horse (3)
Monkey (9)
Orangutan (3)
Pig (3)
Rabbit (3)
IHC (22)
IHC-P (7)
WB (36)
ELISA (18)
Peptide-ELISA (1)
rabbit (36)
mouse (6)
Product Group
IHCPlus (2)
IgG (24)
IgG1 (5)
IgG1,k (1)
monoclonal mc (6)
polyclonal pc (36)
3D6-G6 (1)
OTI6E6 (2)
OTI7C11 (2)
APC Conjugated (3)
Azide-free (2)
Biotin Conjugated (5)
Carrier-free (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (21)
Internal (7)
aa331-361 (7)
aa1-257 (4)
aa325-374 (4)
aa76-125 (4)
50-130 aa, Internal (1)
Tyr108 (1)
No (42)
DUSP4 / MKP2 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DUSP4 / MKP2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa325-374) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
DUSP4 / MKP2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa325-374) (HRP) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
DUSP4 / MKP2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa325-374) (Biotin) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
DUSP4 / MKP2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa325-374) (FITC) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
DUSP4 / MKP2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (aa331-361) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DUSP4 / MKP2 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using DUSP4 Polyclonal Antibody at dilution of 1:30.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
Select
DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
200 µl/$952
Select
DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
200 µl/$952
Select
DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) (APC) Antibody
Human
ELISA, IHC
APC Conjugated
200 µl/$952
Select
DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) (PE) Antibody
Human
ELISA, IHC
PE Conjugated
200 µl/$952
Select
DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Internal) (Azide-free) (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated, Azide-free
200 µl/$952
DUSP4 / MKP2 Antibody - DUSP4 monoclonal antibody (M01), clone 3D6-G6 Western Blot analysis of DUSP4 expression in HeLa.
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DUSP4 / MKP2 Mouse anti-Human Monoclonal (3D6-G6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
DUSP4 / MKP2 Antibody - Western blot of MKP-2 antibody
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (50-130 aa, Internal) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DUSP4 / MKP2 Antibody - IHC of MKP-2 (Y108) pAb in paraffin-embedded human brain tissue.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal (Tyr108) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
DUSP4 / MKP2 Antibody - 1:100 staining rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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DUSP4 / MKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 42 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).