DUSP6 / MKP3

dual specificity phosphatase 6

MKP3 / DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

DUSP6 / MKP3 (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human DUSP6 / MKP3 Protein (Recombinant His) (aa1-381) - LS-G2990

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$554; 10 µg/$292; 50 µg/$411; 250 µg/$1,100; 500 µg/$1,579

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Human DUSP6 / MKP3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65480

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

20 µg/$1,107

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Human DUSP6 / MKP3 Protein (Recombinant His-S) (aa1-300) - LS-G25678

Source:

E. coli

Tag:

His-S

Molecular Weight:

40.6 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human DUSP6 / MKP3 Protein (Recombinant GST) (Full Length) - LS-G28268

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.65 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DUSP6 / MKP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75642

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

20 µg/$150

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DUSP6 / MKP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118283

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

100 µg/$494

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