EP300 / p300

E1A binding protein p300

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

EP300 / p300 (7)

Publications

No (7)

Tag

DDK,C-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

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Human EP300 / p300 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75666

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

264 kDa

Price:

20 µg/$215

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Human EP300 / p300 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118583

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

264 kDa

Price:

100 µg/$710

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Human EP300 / p300 Protein (Recombinant His, N-Terminal) (aa1351-1601) - LS-G24698

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.2 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human EP300 / p300 Protein (Recombinant GST, N-terminus) (aa731-830) - LS-G58458

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EP300 / p300 Protein (Recombinant DDK,C-terminus) - LS-G142315

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

75 kDa

Price:

20 µg/$677

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Rat EP300 / p300 Protein (Recombinant His-GST) (aa1-158) - LS-G24699

Source:

E. coli

Tag:

His-GST

Molecular Weight:

46.0 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Mouse EP300 / p300 Protein (Recombinant His-T7) (aa2124-2397) - LS-G14847

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.2 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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