EPHA4 / EPH Receptor A4

EPH receptor A4

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

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Products

Proteins (17)

Type

Recombinant (17)

Target

EPHA4 / EPH Receptor A4 (17)

Publications

No (17)

Tag

DDK (Flag)-His, C-terminus (1)

Fc (2)

Fc, C-terminus (2)

Fc-His, C-terminus (1)

GST (2)

GST, N-terminus (1)

His (3)

His/GST,N-terminus (1)

His-GST (1)

Species

Human (13)

Mouse (2)

Rat (2)

Source

E. coli (1)

HEK 293 Cells (2)

Human Cells (7)

Insect Cells (1)

Mammalian Cells (3)

Wheat Germ Extract (3)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (12)

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant His-GST) (aa621-882) - LS-G25417

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.7 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant) (Val20-Thr547) - LS-G40106

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.2kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant Fc, C-terminus) (Val20-Thr547) - LS-G40033

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

85.6kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant GST, N-terminus) (aa887-986) - LS-G58465

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant His) (Met1-Thr547) - LS-G97417

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

60 kDa

Price:

100 µg/$721

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Mouse EPHA4 / EPH Receptor A4 Protein (Recombinant Fc) (Met1-Thr547) - LS-G98136

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.3 kDa

Price:

200 µg/$661

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Rat EPHA4 / EPH Receptor A4 Protein (Recombinant Fc) (Met1-Tyr547) - LS-G98386

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.3 kDa

Price:

200 µg/$1,148

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Mouse EPHA4 / EPH Receptor A4 Protein (Recombinant His) (Met1-Thr547) - LS-G98766

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

60 kDa

Price:

200 µg/$1,148

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant) (Val20-Thr547) - LS-G139035

Source:

Mammalian Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.2 kDa

Price:

10 µg/$277; 50 µg/$389

Select

Human EPHA4 / EPH Receptor A4 Protein (Recombinant) (Val20-Thr547) - LS-G139076

Source:

Mammalian Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.6 kDa

Price:

10 µg/$277; 50 µg/$389

Select

Human EPHA4 / EPH Receptor A4 Protein (Recombinant Fc, C-terminus) - LS-G136816

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.6 kDa

Price:

50 µg/$453; 10 µg/$298; 1 mg/$2,064; 500 µg/$1,470

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant Fc-His, C-terminus) (Met1-Thr547) - LS-G138031

Source:

HEK 293 Cells

Tag:

Fc-His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86.5 kDa

Price:

100 µg/$721

Select

Human EPHA4 / EPH Receptor A4 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142211

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

61 kDa

Price:

20 µg/$1,107

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant His/GST,N-terminus) (Ser570-Val986) - LS-G140000

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75 kDa

Price:

50 µg/$707

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant GST) (Full Length) - LS-G28364

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

136.3 kDa

Price:

2 µg/$439

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Human EPHA4 / EPH Receptor A4 Protein (Recombinant GST) (Full Length) - LS-G28365

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

37.18 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Rat EPHA4 / EPH Receptor A4 Protein (Recombinant His) (Met1-Thr547) - LS-G98385

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.8 kDa

Price:

200 µg/$1,148

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