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ER Alpha / Estrogen Receptor

estrogen receptor 1

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

Gene Name: estrogen receptor 1
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: ESR1, Era, ERalpha, Estrogen receptor, ER-alpha, Estrogen receptor 1, NR3A1, ER, ESR, ESRA, Estrogen receptor alpha
Target Sequences: NM_000125 NP_000116.2 P03372

Publications (3)

1
Altered Expression of ESR1, ESR2, PELP1 and c-SRC Genes Is Associated with Ovarian Cancer Manifestation. Monika Englert-Golon, Miroslaw Andrusiewicz, Aleksandra Zbikowska, Malgorzata Chmielewska, Stefan Sajdak, Malgorzata Kotwicka. International journal of molecular sciences. 2021 Jun;22:6216. [Full Text Article] [PubMed:34207568] [PMC:PMC8228770]
2
Effect of Sex Steroids and PGF2a on the Expression of Their Receptors and Decorin in Bovine Caruncular Epithelial Cells in Early-Mid Pregnancy. Monika Jamiol, Magdalena Sozoniuk, Jacek Wawrzykowski, Marta Kankofer. Molecules (Basel, Switzerland). 2022 November;27: [Full Text Article] [PubMed:36364246] [PMC:PMC9653824] Related Antibodies: LS-C167830.
3
Progression of mouse skin carcinogenesis is associated with increased ER alpha levels and is repressed by a dominant negative form of ER alpha . Logotheti S, Papaevangeliou D, Michalopoulos I, Sideridou M, Tsimaratou K, Christodoulou I, Pyrillou K, Gorgoulis V, Vlahopoulos S, Zoumpourlis V. PloS one. 2012 7:e41957. [Full Text Article] [PubMed:22870269] [PMC:PMC3411716] Related Antibodies: LS-B2664.

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ER Alpha / Estrogen Receptor ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$669
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ER Alpha / Estrogen Receptor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.63 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ER Alpha / Estrogen Receptor ELISA Kit
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DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
ER Alpha / Estrogen Receptor ELISA Kit
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DNA Binding
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$694
ER Alpha / Estrogen Receptor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ER Alpha / Estrogen Receptor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ER Alpha / Estrogen Receptor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ER Alpha / Estrogen Receptor ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
ER Alpha / Estrogen Receptor ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ER Alpha / Estrogen Receptor ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ER Alpha / Estrogen Receptor ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ER Alpha / Estrogen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).