ER Alpha / Estrogen Receptor

estrogen receptor 1

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

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Products

ELISA Kits (36)

Type

Cell-Based (1)

Cell-Based Phosphorylation (4)

Competitive EIA (4)

Custom (2)

DNA Binding (1)

DNA Binding Phosphorylation (1)

Sandwich (21)

Sandwich CLIA (2)

Target

ER Alpha / Estrogen Receptor (36)

Reactivity

Human (15)

Mouse (14)

Rat (8)

Chicken (2)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Product Group

Coronavirus Detection (36)

ELISA Kits for Associated Targets (36)

Format

12 x 8-Well Microstrips (4)

96-Well Microplate (8)

96-Well Strip Plate (24)

Publications

No (36)

Sample Type

Adherent Cell Cultures (5)

Cell Lysates (5)

Nuclear Lysates (2)

Plasma (20)

Serum (20)

Tissue Homogenates (9)

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Mouse/Human ER Alpha / Estrogen Receptor (Cell-Based ELISA) ELISA Kit - LS-F1976

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F6267

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

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Human ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F4409

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Mouse ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F22233

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F23792

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F11394

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Mouse ER Alpha / Estrogen Receptor (CLIA) ELISA Kit - LS-F30661

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Rat ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F11393

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human ER Alpha / Estrogen Receptor (CLIA) ELISA Kit - LS-F29760

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F36881

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F4328

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$750

Select

Human ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F26845

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Mouse/Human Phospho-ER Alpha / Estrogen Receptor (Ser118) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1503

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Chicken ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F11395

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F35523

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F31990

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.469 - 30 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ER Alpha / Estrogen Receptor (Custom ELISA) ELISA Kit - LS-F50370

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$610

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Chicken ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43650

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43652

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Guinea pig ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43653

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

3.125 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Porcine ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43654

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43655

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

2.5 - 160 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Sheep ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F43656

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

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Rat ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F53765

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,018

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Human ER Alpha / Estrogen Receptor (Sandwich ELISA) ELISA Kit - LS-F36882

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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