Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
ERBB2 / HER2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
| Gene Name: | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Family/Subfamily: | Protein Kinase , EGF Receptor |
| Synonyms: | ERBB2, C-erb B2/neu protein, CD340, HER2, Herstatin, MLN 19, HER-2, Neu, NGL, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, CD340 antigen, MLN19, p185erbB2, TKR1 |
| Target Sequences: | NM_004448 NP_004439.2 P04626 |
Publications (2)
1
Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. Kawano S, Ikeda W, Kishimoto M, Ogita H, Takai Y. The Journal of biological chemistry. 2009 284:23793-805. (IP)
[PubMed:19561085]
[PMC:PMC2749152]
2
Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway. Nesrine Ebrahim, Hajir A Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman Abd El Aziz M El Gebaly, Nashwa Hassan Abo-Rayah, Dina Sabry, Mohamed El-Sherbiny, Abdelmonem G Madboly, Noha Ibrahim Hussien, Raja El Hasnaoui Saadani, Hasnaa Ali Ebrahim, Omnia A M Badr, Nehal M Elsherbiny, Rabab F Salim. International journal of molecular sciences. 2022 May;23: [Full Text Article]
[PubMed:35682646]
[PMC:PMC9181089]
☰ Filters
Products
Proteins
(41)
Type
Over-Expression Lysate
(5)
Recombinant
(36)
Target
ERBB2 / HER2
(41)
Application
Bind
(4)
ELISA
(4)
Func
(4)
SDS-PAGE
(8)
Publications
No
(41)
Tag
6His, C-terminus
(4)
6His, N-terminus
(3)
DDK (Flag)-His, C-terminus
(1)
DDK,C-terminus
(4)
Fc
(1)
Fc, C-terminus
(3)
Fc-AVI, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(1)
His, N-Terminal
(1)
His,C-terminus
(7)
His-GST
(2)
His-GST, N-terminus
(1)
His-T7
(1)
Human IgG Fc, C-terminus
(2)
Myc-DDK (Flag)
(6)
Species
Human
(28)
Mouse
(5)
Rat
(6)
Source
293T Cells
(2)
Baculovirus
(1)
CHO Cells
(1)
E. coli
(7)
HEK 293 Cells
(18)
Human
(1)
Human Cells
(4)
Mammalian Cells
(2)
Sf9 Cells
(3)
Wheat Germ Extract
(2)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(21)
Biologically Active
Biologically active
(4)
E. coli
6His, N-terminus
73.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
6His, N-terminus
100 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
Wheat Germ Extract
GST
164.45 kDa
2 µg/$439
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.
100 µg/$488; 1 mg/$2,393
HEK 293 Cells
6His, N-terminus
70-80 kDa
100 µg/$298
HEK 293 Cells
Human IgG Fc, C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$1,991
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
96.5kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, rh ErbB2 migrates as an approximately 100-110 kDa protein in SDS-PAGE under reducing conditions.
100 µg/$480; 1 mg/$2,324
E. coli
His, N-Terminal
42.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-GST
49.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.3kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
70.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse ERBB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 872 amino acids and has a calculated molecular mass of 96.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 120-130 kDa in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,003
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse ERBB2 comprises 642 amino acids and has a calculated molecular mass of 71.1 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 100-110 kDa in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,003
Baculovirus
His-GST, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ErbB2 (676-1255)/GST chimera consists of 817 amino acids and predictes a molecular mass of 92 kDa. It migrates as an approximately 100 kDa band in SDS-PAGE under reducing conditions.
50 µg/$364
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa.
50 µg/$372; 500 µg/$1,285
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ERBB2 consists of 184 amino acids and predicts a molecular mass of 20.9 kDa.
50 µg/$348; 200 µg/$570
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
71.1 kDa
100 µg/$721
293T Cells
Myc-DDK (Flag)
134.7 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
137.7 kDa
20 µg/$215
HEK 293 Cells
Myc-DDK (Flag)
137.7 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
134.7 kDa
20 µg/$1,107
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
70.6 kDa
50 µg/$843
Sf9 Cells
DDK,C-terminus
64 kDa
20 µg/$677
Viewing 1-25
of 41
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
