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ERBB3 / HER3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

ERBB3 / HER3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Gene Name: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Family/Subfamily: Protein Kinase , EGF Receptor
Synonyms: ERBB3, C-erbB-3, C-erbB3, ErbB-3, HER3, p85-sErbB3, p45-sErbB3, MDA-BF-1, ErbB3-S, LCCS2, p180-ErbB3
Target Sequences: NM_001982 NP_001973.2 P21860

Publications (2)

1
High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Davies S, Holmes A, Lomo L, Steinkamp MP, Kang H, Muller CY, Wilson BS. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2014 33:402-10. (IHC; Human) [Full Text Article] [PubMed:24901400] [PMC:PMC4153698] Related Antibodies: LS-B2126.
2
Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer. Roßner F, Gieseler C, Morkel M, Royer HD, Rivera M, Bläker H, Dietel M, Schäfer R, Sers C. Oncogenesis. 2016 5:e187. (IHC, WB; Human) [Full Text Article] [PubMed:26779809] [PMC:PMC4728680]

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Products
ELISA Kits (12)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (4)
Sandwich (5)
ERBB3 / HER3 (12)
Human (9)
Mouse (4)
Rat (3)
96-Well Microplate (4)
96-Well Strip Plate (8)
No (12)
Adherent Cell Cultures (3)
Cell Culture Supernatants (3)
Cell Lysates (1)
Plasma (6)
Serum (6)
Tissue Homogenates (2)
ERBB3 / HER3 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ERBB3 / HER3 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ERBB3 / HER3 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ERBB3 / HER3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
ERBB3 / HER3 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
3.43 - 833.3 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
ERBB3 / HER3 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
ERBB3 / HER3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
ERBB3 / HER3 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
ERBB3 / HER3 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
ERBB3 / HER3 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
ERBB3 / HER3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
ERBB3 / HER3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).