ERG

v-ets avian erythroblastosis virus E26 oncogene homolog

ERG is a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.

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Products

Proteins (12)

Type

Over-Expression Lysate (6)

Recombinant (6)

Target

ERG (12)

Publications

No (12)

Tag

GST (1)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (8)

Species

Human (9)

Source

293T Cells (3)

HEK 293 Cells (5)

Wheat Germ Extract (3)

Yeast (1)

Purification

Purified (1)

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Human ERG Protein (Recombinant His) (Full Length) - LS-G22912

Source:

Yeast

Tag:

His

Molecular Weight:

56.6 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human ERG Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G58486

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ERG Protein (Recombinant GST, N-terminus) (aa1-120) - LS-G58487

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ERG Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67174

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

20 µg/$1,107

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Human ERG Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67175

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$1,107

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Human ERG Protein (Recombinant GST) (Full Length) - LS-G28384

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.43 kDa

Price:

2 µg/$439

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ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100297

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

100 µg/$710

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Human ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79284

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.4 kDa

Price:

20 µg/$150

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Human ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79285

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$215

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Human ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79286

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

20 µg/$150

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ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102534

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

100 µg/$494

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ERG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125668

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.4 kDa

Price:

100 µg/$494

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