ESRRA / ERR Alpha

estrogen-related receptor alpha

Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ESRRA / ERR Alpha (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human ESRRA / ERR Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65569

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$1,107

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Human ESRRA / ERR Alpha Protein (Recombinant GST, N-terminus) (aa1-423) - LS-G56247

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human ESRRA / ERR Alpha Protein (Recombinant GST, N-terminus) (aa231-330) - LS-G58492

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ESRRA / ERR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75813

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46 kDa

Price:

20 µg/$150

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ESRRA / ERR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116636

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46 kDa

Price:

100 µg/$494

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Human ESRRA / ERR Alpha Protein (Recombinant GST) (Full Length) - LS-G28390

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.9 kDa

Price:

2 µg/$439

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