F13A1 / Factor XIIIa

coagulation factor XIII, A1 polypeptide

F13A1 / Factor XIIIa is the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

F13A1 / Factor XIIIa (10)

Publications

No (10)

Tag

6His, C-terminus (1)

6His, N-terminus (1)

GST (1)

His,C-terminus (1)

His-T7 (3)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Human (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human F13A1 / Factor XIIIa Protein (Recombinant 6His, C-terminus) (Gly39-Met732) - LS-G55664

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,377; 1 mg/$1,765

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Human F13A1 / Factor XIIIa Protein (Recombinant GST) (Full Length) - LS-G28422

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.26 kDa

Price:

10 µg/$479; 25 µg/$670

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Human F13A1 / Factor XIIIa Protein (Recombinant 6His, N-terminus) (aa39-732) - LS-G57166

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Mouse F13A1 / Factor XIIIa Protein (Recombinant His-T7) (aa372-616) - LS-G13358

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.3 kDa

Price:

50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human F13A1 / Factor XIIIa Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65275

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.2 kDa

Price:

20 µg/$1,107

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F13A1 / Factor XIIIa Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98929

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.28 kDa

Price:

100 µg/$494

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Human F13A1 / Factor XIIIa Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75233

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.28 kDa

Price:

20 µg/$150

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Human F13A1 / Factor XIIIa Protein (Recombinant His,C-terminus) (Gly39-Met732) - LS-G139826

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80.3 kDa

Price:

10 µg/$376; 50 µg/$526

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Rat F13A1 / Factor XIIIa Protein (Recombinant His-T7) (aa140-377) - LS-G24207

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.0 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human F13A1 / Factor XIIIa Protein (Recombinant His-T7) (aa107-345) - LS-G13357

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.0 kDa

Price:

50 µg/$412; 10 µg/$276; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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