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Thrombin Receptor is a Proteinase-Activated Receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. Thrombin induced RANTES expression through a PAR-1 mediated pathway influences inflammatory cell migration to the synovium in patients with rheumatoid arthritis.
Gene Name: | coagulation factor II (thrombin) receptor |
Family/Subfamily: | GPCR , Proteinase-activated |
Synonyms: | F2R, CF2R, Coagulation factor II receptor, PAR1, PAR-1, Thrombin receptor, TR, HTR, Protease-activated receptor 1 |
Target Sequences: | NM_001992 NP_001983.2 P25116 |
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