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F2RL2 / PAR3 is a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Gene Name: | coagulation factor II (thrombin) receptor-like 2 |
Family/Subfamily: | GPCR , Proteinase-activated |
Synonyms: | F2RL2, PAR-3, Thrombin receptor-like 2, PAR3, Protease-activated receptor 3 |
Target Sequences: | NM_004101 NP_004092.1 O00254 |
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