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F9 / Factor IX
coagulation factor IX
F9 / Factor IX is a vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
| Gene Name: | coagulation factor IX |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | F9, Christmas Disease, Coagulation factor IX, Factor IX Deficiency, FIX, HEMB, F9 p22, Factor 9, Factor IX, Factor IX F9, FIX F9, Haemophilia B, THPH8, Christmas factor, Hemophilia B, PTC, Serine protease |
| Target Sequences: | NM_000133 NP_000124.1 P00740 |
Publications (4)
1
Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells. Li SJ, Luo Y, Zhang LM, Yang W, Zhang GG. Molecular medicine reports. 2017 March;15:1313-1318. [Full Text Article]
[PubMed:28112377]
[PMC:PMC5367337]
2
Preclinical development of plant-based oral immune modulatory therapy for haemophilia B. Aparajitha Srinivasan, Roland W Herzog, Imran Khan, Alexandra Sherman, Thais Bertolini, Tung Wynn, Henry Daniell. Plant biotechnology journal. 2021 Oct;;19:1952-1966. [Full Text Article]
[PubMed:33949086]
[PMC:PMC8486253]
3
A novel next-generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys. Brian Lauritzen, Mads Bjelke, Olle Björkdahl, Esther Bloem, Kevin Keane, Marianne Kjalke, Marie Rossen, Solvej Lund Lippert, Karin Nana Weldingh, Mikala Skydsgaard, Stine Kjellev. Journal of thrombosis and haemostasis : JTH. 2022 June;20:1312-1324. [Full Text Article]
[PubMed:35191180]
[PMC:PMC9314625]
Related Antibodies: LS-B7226.
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F9 / Factor IX Goat anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
250 µg/$485
F9 / Factor IX Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, RIA, WB
Unconjugated
100 µg/$518
F9 / Factor IX Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
100 µg/$611
F9 / Factor IX Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$611
F9 / Factor IX Mouse anti-Human Monoclonal (13F42-F6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.25 mg/$575
F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, Neut
Unconjugated
100 µg/$575
F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
0.5 mg/$460
F9 / Factor IX Rabbit anti-Human Polyclonal (aa48-191) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
F9 / Factor IX Mouse anti-Human Monoclonal (1C2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$824
F9 / Factor IX Mouse anti-Human Monoclonal (CaFIX-1) Antibody
Human
ELISA, WB
Unconjugated
200 µg/$503
F9 / Factor IX Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$335; 1 mg/$417; 10 mg/$2,196
F9 / Factor IX Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$824
F9 / Factor IX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
F9 / Factor IX Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
F9 / Factor IX Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
F9 / Factor IX Rat anti-Mouse Monoclonal (9041) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$598
F9 / Factor IX Rabbit anti-Human Monoclonal (Preservative Free) (044) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
F9 / Factor IX Rabbit anti-Human Polyclonal (aa217-453) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
F9 / Factor IX Mouse anti-Human Monoclonal (F9-1) Antibody
Human
ELISA
Unconjugated
500 µg/$657
F9 / Factor IX Chicken anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
1 mg/$572
F9 / Factor IX Rabbit anti-Human Polyclonal (aa232-455) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
F9 / Factor IX Rabbit anti-Human Monoclonal (Preservative Free) (014) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
F9 / Factor IX Mouse anti-Human Monoclonal (13F42-F6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
1 mg/$731; 10 mg/$4,976
F9 / Factor IX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
F9 / Factor IX Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$533
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