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FASLG / Fas Ligand

Fas ligand (TNF superfamily, member 6)

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Gene Name: Fas ligand (TNF superfamily, member 6)
Family/Subfamily: TNF , not assigned-TNF
Synonyms: FASLG, ALPS1B, Apoptosis antigen ligand, APTL, CD95L, CD95 ligand, CD178 antigen, CD95-L, Fas antigen ligand, Fas ligand, FASL, TNFSF6, APT1LG1, CD178
Target Sequences: NM_000639 NP_000630.1 P48023

Publications (9)

1
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. Strauss L, Bergmann C, Whiteside TL. Journal of immunology (Baltimore, Md. : 1950). 2009 182:1469-80. [PubMed:19155494] Related Antibodies: LS-C40984.
2
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Li JH, D'Alessio A, Pober JS. The American journal of pathology. 2009 175:1124-35. [PubMed:19661440] [PMC:PMC2731131] Related Antibodies: LS-C40984.
3
Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways. Krger K, Agnischock S, Lechtermann A, Tiwari S, Mishra M, Pilat C, Wagner A, Tweddell C, Gramlich I, Mooren FC. Journal of applied physiology (Bethesda, Md. : 1985). 2011 110:1226-32. [PubMed:21393471] Related Antibodies: LS-C40984.
4
Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. Khalid M, Yu H, Sauter D, Usmani SM, Schmokel J, Feldman J, Gruters RA, van der Ende ME, Geyer M, Rowland-Jones S, Osterhaus AD, Kirchhoff F. Journal of virology. 2012 86:4906-20. [PubMed:22345473] [PMC:PMC3347365] Related Antibodies: LS-C40984.
5
Phenotypic and functional characterization of human T-cell subsets in response to influenza A viruses. Qin G, Liu Y, Zheng J, Xiang Z, Ng IH, Malik Peiris JS, Lau YL, Tu W. The Journal of infectious diseases. 2012 205:1646-53. [PubMed:22457284] Related Antibodies: LS-C40984.
6
CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons. Shrestha B, Pinto AK, Green S, Bosch I, Diamond MS. Journal of virology. 2012 86:8937-48. [PubMed:22740407] [PMC:PMC3416144] Related Antibodies: LS-C40984.
7
Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism. Mooren FC, Vlker K, Klocke R, Nikol S, Waltenberger J, Krger K. Journal of applied physiology (Bethesda, Md. : 1985). 2012 113:1082-90. [PubMed:22858628] Related Antibodies: LS-C40984.
8
IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human) [Full Text Article] [PubMed:29468159] [PMC:PMC5807897] Related Antibodies: LS-C176019.
9
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]
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FASLG / Fas Ligand Antibody - Anti-FASLG / FASL antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
FASLG / Fas Ligand Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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CHO Cells
His, N-Terminal
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.9 kDa
2 µg/$268; 10 µg/$349
FASLG / Fas Ligand ELISA Kit
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Sandwich
96-Well Microplate
Pig
23.44 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
FASLG / Fas Ligand Antibody - Human Fas Ligand transfected cells stained with purified NOK-1, followed by biotinylated anti-mouse IgG and Sav-PE
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FASLG / Fas Ligand Mouse anti-Human Monoclonal (NOK-1) Antibody
Human
Flo, ICC, IF, IP
Unconjugated
100 µg/$325
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HEK 293 Cells
DDK (Flag)
Less than 0.05 EU/µg protein (determined by LAL method).
~33kDa (SDS-PAGE)
10 µg/$323
FASLG / Fas Ligand Antibody - Western blot of FAS ligand/TNFL6 (P137) pAb in extracts from A549 cells.
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal (Pro137) Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
FASLG / Fas Ligand ELISA Kit
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Sandwich
96-Well Microplate
Human
1.37 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
FASLG / Fas Ligand Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FAS ligand Antibody. The picture on the right is blocked with the synthesized peptide.
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FASLG / Fas Ligand Antibody - Immunofluorescence of monoclonal antibody to TNFSF6 on HeLa cell. [antibody concentration 10 ug/ml]
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FASLG / Fas Ligand Mouse anti-Human Monoclonal (2G9-G8) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
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E. coli
His, N-Terminal
21.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
FASLG / Fas Ligand Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$380
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FASLG / Fas Ligand Rat anti-Mouse Monoclonal (H11) Antibody
Mouse
Flo, ICC, WB
Unconjugated
100 µg/$505
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FASLG / Fas Ligand Rat anti-Mouse Monoclonal Antibody
Mouse
Flo, IHC
Unconjugated
100 µg/$490
FASLG / Fas Ligand Antibody - 1:100 staining human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FASLG / Fas Ligand Antibody - Western blot of 293 cell lysate using FASL Antibody
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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FASLG / Fas Ligand Rabbit anti-Mouse Monoclonal (Preservative Free) (001) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
FASLG / Fas Ligand Antibody - Western blot of recombinant FASLG / FASL / Fas Ligand.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FASLG / Fas Ligand Rabbit anti-Rhesus monkey Polyclonal (aa102-280) (Biotin) Antibody
Rat, Rhesus monkey
WB
Biotin Conjugated
100 µl/$335; 200 µl/$389; 500 µl/$568; 1 ml/$688; 2 ml/$925; 5 ml/$1,564
FASLG / Fas Ligand Antibody - Western blot of FAS-L antibody
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal (70-150 aa, Internal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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FASLG / Fas Ligand Mouse anti-Human Monoclonal (NOK-1) Antibody
Human
Flo, Func, ICC, IP, WB
Unconjugated
0.1 mg/$302
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FASLG / Fas Ligand Mouse anti-Human Monoclonal (Low Endotoxin) (NOK-1) Antibody
Human
Flo, Func, ICC, IP, WB
Unconjugated, Low Endotoxin
0.1 mg/$302
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$564
FASLG / Fas Ligand Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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FASLG / Fas Ligand Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FASLG / Fas Ligand ELISA Kit
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Sandwich
96-Well Microplate
Mouse
8.19 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
FASLG / Fas Ligand ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Viewing 1-25 of 176 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).