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The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Gene Name: | fatty acid synthase |
Synonyms: | FASN, Fatty acid synthase, OA-519, SDR27X1 |
Target Sequences: | NM_004104 NP_004095.4 P49327 |
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