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FASN / Fatty Acid Synthase

fatty acid synthase

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Gene Name: fatty acid synthase
Synonyms: FASN, Fatty acid synthase, OA-519, SDR27X1
Target Sequences: NM_004104 NP_004095.4 P49327

Publications (8)

1
FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Dridi S, Ververken C, Hillgartner FB, Arckens L, Lutgarde A, Van der Gucht E, Cnops L, Decuypere E, Buyse J. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 291:R138-47. [PubMed:16455759]
2
Androgen deprivation increases p300 expression in prostate cancer cells. Heemers HV, Sebo TJ, Debes JD, Regan KM, Raclaw KA, Murphy LM, Hobisch A, Culig Z, Tindall DJ. Cancer research. 2007 67:3422-30. [PubMed:17409453]
3
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. Vvere AL, Kridel SJ, Wheeler FB, Lewis JS. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 49:327-34. [PubMed:18199615]
4
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Bryzgalova G, Lundholm L, Portwood N, Gustafsson JA, Khan A, Efendic S, Dahlman-Wright K. American journal of physiology. Endocrinology and metabolism. 2008 295:E904-12. [PubMed:18697913] [PMC:PMC2575902]
5
A selective estrogen receptor agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. Chow JD, Jones ME, Prelle K, Simpson ER, Boon WC. The Journal of endocrinology. 2011 210:323-34. (WB; Mouse) [PubMed:21705395]
6
Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis. Oliva J, French SW, Li J, Bardag-Gorce F. Experimental and molecular pathology. 2012 93:26-34. (WB; Rat) [PubMed:22445925]
7
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]
8
Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma10<sup> Department of Medicine, University of Rochester Medical Center, Rochester, NY, United States12<sup> Bioinformatics Core, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States14<sup> Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma, OK, United States16<sup> Department of Medicine, Duke Cancer Institute, Duke University Medical Center, Dur. Dashnamoorthy Ravi , Afshin Beheshti , Nasséra Abermil, Frederick Lansigan , William Kinlaw, Nirupa R Matthan, Maisarah Mokhtar, Frank C Passero Jr, Patrick Puliti , Kevin A David , Gregory G Dolnikowski, Xiaoyang Su , Ying Chen, Mahboubi Bijan, Rohan R Varshney, Baek Kim , Sandeep S Dave, Michael C Rudolph, Andrew M Evens. Frontiers in oncology. 2021 Oct;11:725137. [Full Text Article] [PubMed:34765544] [PMC:PMC8576537] Related Antibodies: LS-C104946.
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FASN / Fatty Acid Synthase Antibody - Anti-Fatty Acid Synthase antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa942-973) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
FASN / Fatty Acid Synthase Antibody - Anti-Fatty Acid Synthase antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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FASN / Fatty Acid Synthase Goat anti-Human Polyclonal (aa2118-2129) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
FASN / Fatty Acid Synthase Antibody - Immunofluorescence of monoclonal antibody to FASN on HeLa cell (antibody concentration 10 ug/ml).
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FASN / Fatty Acid Synthase Mouse anti-Human Monoclonal (3F2-1F3) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$423
FASN / Fatty Acid Synthase ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
FASN / Fatty Acid Synthase Antibody - Anti-FASN / Fatty Acid Synthase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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FASN / Fatty Acid Synthase Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Chicken, Rat, Mouse, Pig, Primate, Human
IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
FASN / Fatty Acid Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
FASN / Fatty Acid Synthase Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa1175-1225) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
FASN / Fatty Acid Synthase Antibody - Detection of Human and Mouse FASN by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-FASN used at a dilution of 1:200 (1 Detection: DAB.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa2462-2511) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
FASN / Fatty Acid Synthase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FASN / Fatty Acid Synthase Antibody - Immunohistochemistry of paraffin-embedded human colon using FASN antibody at dilution of 1:100 (40x lens).
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IP, WB
Unconjugated
20 µl/$299; 100 µl/$427
FASN / Fatty Acid Synthase Antibody - Human Breast, Adipocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC-P, IP, WB
Unconjugated
50 µl/$460
FASN / Fatty Acid Synthase Protein - Recombinant Fatty Acid Synthase By SDS-PAGE
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E. coli
His
28.7 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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E. coli
6His, N-terminus
41.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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FASN / Fatty Acid Synthase Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
IF, IP, WB
Unconjugated
100 µl/$391
FASN / Fatty Acid Synthase Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FASN / Fatty Acid Synthase Antibody - Human Adipocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
FASN / Fatty Acid Synthase Antibody - IHC of paraffin-embedded OVCAR3 xenograft using Fatty Acid Synthase antibody at 1:500 dilution.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa7-287) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
FASN / Fatty Acid Synthase Antibody - IHC of paraffin-embedded OECM1 xenograft using Fatty Acid Synthase antibody at 1:500 dilution.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa401-694) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P
Unconjugated
100 µl/$412
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
FASN / Fatty Acid Synthase Antibody - Immunohistochemistry of paraffin-embedded human lung tissue using antibody at dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FASN / Fatty Acid Synthase Rabbit anti-Human Polyclonal (aa2155-2495) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
FASN / Fatty Acid Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
FASN / Fatty Acid Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
FASN / Fatty Acid Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
FASN / Fatty Acid Synthase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
273.2 kDa
20 µg/$215
Viewing 1-25 of 115 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).