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FGF2 / Basic FGF

fibroblast growth factor 2 (basic)

FGF2 / Basic FGF is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

Gene Name: fibroblast growth factor 2 (basic)
Family/Subfamily: HBGF , not assigned-HBGF
Synonyms: FGF2, Basic fibroblast growth factor, FGFB, Fibroblast growth factor 2, FGF-2, Prostatropin, BFGF, HBGF-2
Target Sequences: NM_002006 NP_001997.5 P09038

Publications (1)

1
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma10<sup> Washington University School of Medicine, St. Louis, MO, USA12<sup> Memorial Sloan Kettering Cancer Center, New York, NY, USA14<sup> GlaxoSmithKline, Inc., 1250 South Collegeville Road, Collegeville, PA, USA16<sup> Utrecht University, Utrecht, The Netherlands18<sup> Phase I Trials Unit, Medical Oncology Department, Hospital Universitario Virgen de. Emilie M J van Brummelen, Evgeny Levchenko, Manuel Dómine, Dean A Fennell, Hedy L Kindler, Santiago Viteri, Shirish Gadgeel, Pilar Garrido López, Vladimir Kostorov, Daniel Morgensztern, Sergey Orlov, Marjorie G Zauderer, Johan F Vansteenkiste, Katherine Baker-Neblett, James Vasquez, Xiaowei Wang, David I Bellovin, Jan H M Schellens, Li Yan, Ionel Mitrica, M Phillip DeYoung, José Trigo. Investigational new drugs. 2020 Apr;;38:457-467. [Full Text Article] [PubMed:31065954] [PMC:PMC6898757] Related Antibodies: LS-B10042.

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Products
Proteins (59)
Over-Expression Lysate (2)
Recombinant (56)
FGF2 / Basic FGF (59)
Animal-free (3)
No (59)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His (4)
His, N-Terminal (4)
His, N-terminus (1)
His,N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Bovine (1)
Cow (1)
Human (34)
Mouse (12)
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Rat (7)
293T Cells (1)
E. coli (54)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (14)
Low endotoxin level (43)
Biologically active (25)
Animal-free (3)
FGF2 / Basic FGF Protein - Recombinant Fibroblast Growth Factor 2, Basic By SDS-PAGE
Select
E. coli
His
16.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
FGF2 / Basic FGF Protein
Select
E. coli
His, N-Terminal
17 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
16.3 kDa
50 µg/$342; 10 µg/$259; 1 mg/$834; 500 µg/$675
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
16.4 kDa (SDS-PAGE)
50 µg/$296; 10 µg/$253; 1 mg/$990
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
17.4 kDa
50 µg/$346; 10 µg/$259; 1 mg/$984; 500 µg/$692
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
17.15 kDa
50 µg/$346; 10 µg/$259; 1 mg/$1,294; 500 µg/$977
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
16.2 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
17.2 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2 kDa
20 µg/$269; 100 µg/$360
Select
E. coli
His,N-terminus
18.5 kDa
100 µg/$360; 20 µg/$269
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.3 kDa
10 µg/$248; 50 µg/$307
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.4 kDa
10 µg/$248; 50 µg/$311
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2 kDa
10 µg/$248; 50 µg/$311
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2 kDa
10 µg/$262; 50 µg/$317
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.2 kDa
10 µg/$262; 50 µg/$317
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
16.2 kDa
10 µg/$288; 50 µg/$436
Select
E. coli
144 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
15.95 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
FGF2 / Basic FGF Protein
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
17.4 kDa
100 µg/$677
FGF2 / Basic FGF Protein - Recombinant Rat FGF2 Protein (His Tag)-Elabscience
Select
E. coli
His, N-terminus
15.2 kDa
20 µg/$270; 100 µg/$390
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 144 amino acid recombinant protein has a predicted molecular mass of 16,223 Da. The DTT-reduced and non-reduced protein migrate at approximately 16kDa by SDS-PAGE. The N-terminal amino acid is Alanine.
10 µg/$272; 25 µg/$306; 100 µg/$424; 500 µg/$1,000
FGF2 / Basic FGF Protein - 3NIH/3T3 cell proliferation induced by human FGFb.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 145 amino acid recombinant protein has a predicted molecular mass of 16,310 Da. The DTT-reduced and non-reduced protein migrate at approximately 18kDa by SDS-PAGE. This protein may or may not contain an N-terminal methionine.
10 µg/$261; 25 µg/$291; 100 µg/$386; 500 µg/$869
FGF2 / Basic FGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
32.4 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
FGF2 / Basic FGF Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
250 µg/$739; 50 µg/$361
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$370
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$370
Viewing 1-25 of 59 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).