FOXA1

forkhead box A1

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

FOXA1 (7)

Publications

No (7)

Tag

GST, N-terminus (3)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human FOXA1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G28864

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

75.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FOXA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65870

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

20 µg/$1,107

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Human FOXA1 Protein (Recombinant GST, N-terminus) (aa287-370) - LS-G58853

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FOXA1 Protein (Recombinant GST, N-terminus) (aa367-472) - LS-G58854

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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FOXA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100310

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

100 µg/$494

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Human FOXA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76433

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

20 µg/$150

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Human FOXA1 Protein (Recombinant His-T7) (aa15-233) - LS-G25698

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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