Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (800) 227-6666


Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

FTH1 / Ferritin Heavy Chain

ferritin, heavy polypeptide 1

FTH1 / Ferritin Heavy Chain is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Gene Name: ferritin, heavy polypeptide 1
Synonyms: FTH1, Apoferritin, Ferritin H subunit, Ferritin heavy chain, Ferritin, heavy polypeptide 1, FHC, FTHL6, PIG15, PLIF, FTH
Target Sequences: NM_002032 NP_002023.2 P02794

Publications (10)

1
Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation. Hasan MR, Tosha T, Theil EC. The Journal of biological chemistry. 2008 283:31394-400. [PubMed:18805796] [PMC:PMC2581568]
2
Redox control of iron regulatory protein 2 stability. Hausmann A, Lee J, Pantopoulos K. FEBS letters. 2011 585:687-92. [PubMed:21281640]
3
Alternative ferritin mRNA translation via internal initiation. Daba A, Koromilas AE, Pantopoulos K. RNA (New York, N.Y.). 2012 18:547-56. [PubMed:22271759] [PMC:PMC3285941]
4
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. Journal of neurochemistry. 2012 123:325-36. (WB; Mouse) [PubMed:22881289]
5
Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. Wen X, Paine ML. BMC research notes. 2013 6:1. (IHC-P; Mouse, Rat) [Full Text Article] [PubMed:23281703] [PMC:PMC3556315] Related Antibodies: LS-B5847.
6
Reabsorption of iron into acutely damaged rat liver: A role for ferritins. Malik IA, Wilting J, Ramadori G, Naz N. World journal of gastroenterology : WJG. 2017 November;23:7347-7358. (Human) [Full Text Article] [PubMed:29151689] [PMC:PMC5685841]
7
Ferritin in glioblastoma. Heidi Jaksch-Bogensperger , Sabine Spiegl-Kreinecker, Paolo Arosio, Peter Eckl, Stefan Golaszewski, Yvonne Ebner, Rahman Al-Schameri, Peter Strasser, Serge Weis , Nikolaus Bresgen. British journal of cancer. 2020 May;122:1441-1444. [Full Text Article] [PubMed:32203223] [PMC:PMC7217840]
8
Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer. Amjad Ali, Jasmin Shafarin, Hema Unnikannan, Nour Al-Jabi, Rola Abu Jabal, Khuloud Bajbouj, Jibran Sualeh Muhammad, Mawieh Hamad. International journal of biological sciences. 2021 November;17:4474-4492. [Full Text Article] [PubMed:34803511] [PMC:PMC8579449] Related Antibodies: LS-B11085.
9
Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis. Monika Lecka, Artur Slomka, Katarzyna Albrecht, Ewa Zekanowska, Michal Romiszewski, Jan Styczynski. Cancers. 2021 June;13:3029. [Full Text Article] [PubMed:34204310] [PMC:PMC8233795]
10
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. Supawadee Sukseree, Uwe Yacine Schwarze, Reinhard Gruber, Florian Gruber, Maria Quiles Del Rey, Joseph D Mancias, John D Bartlett, Erwin Tschachler, Leopold Eckhart. Autophagy. 2020 October;16:1851-1857. [Full Text Article] [PubMed:31880208] [PMC:PMC8386597] Related Antibodies: LS-B5847.
more

☰ Filters
Products
Proteins (18)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (14)
FTH1 / Ferritin Heavy Chain (18)
No (18)
6His, N-terminus (5)
GST (2)
His (3)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (13)
Mouse (1)
Pig (1)
Rat (1)
Sheep (1)
293T Cells (1)
E. coli (11)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (4)
FTH1 / Ferritin Heavy Chain Protein - Recombinant Ferritin, Heavy Polypeptide By SDS-PAGE
Select
E. coli
His, N-Terminal
22.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.2kD
10 µg/$248; 50 µg/$288; 500 µg/$785
FTH1 / Ferritin Heavy Chain Protein - Recombinant Ferritin, Heavy Polypeptide By SDS-PAGE
Select
E. coli
His-T7
25.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
FTH1 / Ferritin Heavy Chain Protein
Select
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
FTH1 / Ferritin Heavy Chain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21 kDa
20 µg/$150
FTH1 / Ferritin Heavy Chain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21 kDa
100 µg/$494
Select
HEK 293 Cells
6His, N-terminus
21 kDa
100 µg/$298
FTH1 / Ferritin Heavy Chain Protein - 12.5% SDS-PAGE of human FTH1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
45.87 kDa
10 µg/$479; 25 µg/$670
FTH1 / Ferritin Heavy Chain Protein - 12.5% SDS-PAGE of human FTH1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
45.87 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
6His, N-terminus
23 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
HEK 293 Cells
6His, N-terminus
21 kDa
200 µl/$283
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.4kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
FTH1 / Ferritin Heavy Chain Protein - Purified recombinant protein FTH1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21 kDa
20 µg/$1,107
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.4 kDa
10 µg/$248; 50 µg/$288
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.2 kDa
10 µg/$248; 50 µg/$288
Select
E. coli
His
22.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
His
21.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
FTH1 / Ferritin Heavy Chain Protein - Recombinant Ferritin, Heavy Polypeptide By SDS-PAGE
Select
E. coli
His
22.6 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Viewing 1-18 of 18 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).