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GALNS / Chondroitinase

galactosamine (N-acetyl)-6-sulfate sulfatase

GALNS / Chondroitinase encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.

Gene Name: galactosamine (N-acetyl)-6-sulfate sulfatase
Synonyms: GALNS, Chondroitinase, Chondroitinsulfatase, GALNAC6S, GalNAc6S sulfatase, GAS, MPS4A, Galactose-6-sulfate sulfatase
Target Sequences: NM_000512 NP_000503.1 P34059

Publications (1)

1
The incorporation of growth factor and chondroitinase ABC into an electrospun scaffold to promote axon regrowth following spinal cord injury. Raymond J Colello, Woon N Chow, John W Bigbee, Charles Lin, Dustin Dalton, Damien Brown, Balendu Shekhar Jha, Bruce E Mathern, Kangmin D Lee, David G Simpson. Journal of tissue engineering and regenerative medicine. 2016 August;10:656-68. [Full Text Article] [PubMed:23950083] Related Antibodies: LS-C61742.

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
GALNS / Chondroitinase (9)
No (9)
GST (2)
GST, N-terminus (1)
His (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
GALNS / Chondroitinase Protein
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Yeast
His
57.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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E. coli
GST
82.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GALNS / Chondroitinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
58.03 kDa
100 µg/$494
GALNS / Chondroitinase Protein - 12.5% SDS-PAGE of human GALNS stained with Coomassie Blue
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Wheat Germ Extract
GST
84.4 kDa
2 µg/$439
GALNS / Chondroitinase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GALNS / Chondroitinase Protein - Purified recombinant protein GALNS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.4 kDa
20 µg/$1,107
GALNS / Chondroitinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
58.03 kDa
20 µg/$150
GALNS / Chondroitinase Protein - Recombinant N-Acetylgalactosamine-6-Sulfatase By SDS-PAGE
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E. coli
His-T7
27.0 kDa
50 µg/$452; 10 µg/$283; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
GALNS / Chondroitinase Protein - Recombinant N-Acetylgalactosamine-6-Sulfatase By SDS-PAGE
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E. coli
His-T7
27.0 kDa
50 µg/$472; 10 µg/$286; 200 µg/$942; 100 µg/$752; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).