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GH / Growth Hormone
growth hormone 1
GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
| Gene Name: | growth hormone 1 |
| Family/Subfamily: | Somatotropin |
| Synonyms: | GH1, Growth hormone, GH, GHN, IGHD1B, GH-N, Pituitary growth hormone, Growth hormone 1, Somatotropin |
| Target Sequences: | NM_000515 NP_000506.2 P01241 |
Publications (3)
1
Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice. Marie-José Lecomte, Chloé Bertolus, Nélina Ramanantsoa, Françoise Saurini, Jacques Callebert, Catherine Sénamaud-Beaufort, Maud Ringot, Thomas Bourgeois, Boris Matrot, Corinne Collet, Jeannette Nardelli, Jacques Mallet, Guilan Vodjdani, Jorge Gallego, Jean-Marie Launay, Sylvie Berrard. Endocrinology. 2018 April;159:1844-1859. [Full Text Article]
[PubMed:29509880]
2
Effect of dietary copper sources on performance, gastric ghrelin-RNA expression, and growth hormone concentrations in serum in piglets. Ricardo Gonzalez-Esquerra, Raquel B Araujo, Douglas Haese, Joao L Kill, Anderson F Cunha, Paulo S Monzani, Cesar G Lima. Journal of animal science. 2019 October;97:4242-4247. [Full Text Article]
[PubMed:31581297]
[PMC:PMC6776305]
3
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q Estrada, Simon Knott, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed. Cell reports. 2021 December;37:110068. [Full Text Article]
[PubMed:34910915]
[PMC:PMC8716125]
Related Antibodies: LS-B4199.
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Proteins
(31)
Type
Over-Expression Lysate
(4)
Recombinant
(26)
Target
GH / Growth Hormone
(31)
Publications
No
(31)
Tag
10His, N-terminus + Myc, C-terminus
(1)
Fc
(1)
GST
(1)
His
(1)
His, N-Terminal
(1)
His-T7
(4)
Myc-DDK (Flag)
(6)
Species
Dog
(1)
Human
(19)
Mouse
(5)
Pig
(3)
Rat
(1)
Source
293T Cells
(2)
CHO Cells
(1)
E. coli
(21)
HEK 293 Cells
(6)
Wheat Germ Extract
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(11)
Biologically Active
Biologically active
(8)
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~22 kDa
50 µg/$291; 200 µg/$517; 1 mg/$1,951
E. coli
His-T7
25.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
None
Less than 1 EU/µg (determined by LAL method).
22 kDa
10 µg/$286; 1 mg/$2,449; 50 µg/$402
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245; 50 µg/$273; 250 µg/$429
E. coli
None
100 µg/$317; 500 µg/$526; 20 µg/$245
E. coli
None
Biologically active
22 kDa
100 µg/$367; 500 µg/$574; 1 mg/$818
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.9kD
10 µg/$288; 50 µg/$442; 500 µg/$1,159; 1 mg/$1,506
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
22.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
Myc-DDK (Flag)
24.7 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
22.8 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
24.7 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
22.8 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
22.8 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
24.7 kDa
100 µg/$494
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
22.1 kDa
10 µg/$281; 50 µg/$389
E. coli
10His, N-terminus + Myc, C-terminus
29.4 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.9 kDa
10 µg/$288; 50 µg/$436
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~22 kDa
500 µg/$291; 1 mg/$353
E. coli
None
Less than 0.1 ng/µg protein.
100 µg/$339; 500 µg/$429; 1000 µg/$523
E. coli
None
Biologically active
22.3 kDa
10 µg/$268; 50 µg/$349
E. coli
None
Biologically active
22.3 kDa
10 µg/$282; 50 µg/$370
HEK 293 Cells
His
23.6 kDa
10 µg/$337; 50 µg/$632; 100 µg/$947
HEK 293 Cells
Fc
48.9 kDa
10 µg/$343; 50 µg/$662; 100 µg/$992
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
20-24 kDa (SDS-PAGE)
50 µg/$521; 10 µg/$286; 1 mg/$2,783
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
22.1 kDa (SDS-PAGE)
50 µg/$286; 10 µg/$245; 1 mg/$389
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