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GLB1 / Beta-Galactosidase

galactosidase, beta 1

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Gene Name: galactosidase, beta 1
Synonyms: GLB1, Acid beta-galactosidase, Beta-galactosidase, Elastin receptor 1, Elastin receptor 1 (67kD), Elastin receptor 1, 67kDa, Galactosidase, beta 1, ELNR1, Lactase, MPS4B
Target Sequences: NM_000404 NP_000395.2 P16278

Publications (5)

1
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. Oncotarget. 2015 6:771-88. (WB; Human) [PubMed:25596733] [PMC:PMC4359254]
2
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M. Cancer research. 2016 76:594-606. (WB; Human) [Full Text Article] [PubMed:26772755] [PMC:PMC4785885] Related Antibodies: LS-B10217.
3
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Kovacovicova K, Skolnaja M, Heinmaa M, Mistrik M, Pata P, Pata I, Bartek J, Vinciguerra M. Frontiers in oncology. 2018 October;8:459. [Full Text Article] [PubMed:30425964] [PMC:PMC6218402] Related Antibodies: LS-B10217.
4
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. Journal of neuroinflammation. 2018 September;15:260. [Full Text Article] [PubMed:30201019] [PMC:PMC6131894] Related Antibodies: LS-B10989.
5
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q Estrada, Simon Knott, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed. Cell reports. 2021 December;37:110068. [Full Text Article] [PubMed:34910915] [PMC:PMC8716125] Related Antibodies: LS-B10989.
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Products
ELISA Kits (19)
Custom (4)
Sandwich (12)
Sandwich CLIA (3)
GLB1 / Beta-Galactosidase (19)
Human (6)
Mouse (4)
Rat (2)
Chicken (1)
Dog (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (2)
96-Well Strip Plate (14)
No (19)
Cell Lysates (1)
Cell Supernatant (1)
Plasma (10)
Serum (10)
Tissue Homogenates (3)
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 mU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.13 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
GLB1 / Beta-Galactosidase ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
GLB1 / Beta-Galactosidase ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
GLB1 / Beta-Galactosidase ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
GLB1 / Beta-Galactosidase ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
78.125 - 5000 U/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 mU/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GLB1 / Beta-Galactosidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).