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GLB1 / Beta-Galactosidase

galactosidase, beta 1

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Gene Name: galactosidase, beta 1
Synonyms: GLB1, Acid beta-galactosidase, Beta-galactosidase, Elastin receptor 1, Elastin receptor 1 (67kD), Elastin receptor 1, 67kDa, Galactosidase, beta 1, ELNR1, Lactase, MPS4B
Target Sequences: NM_000404 NP_000395.2 P16278

Publications (5)

1
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. Oncotarget. 2015 6:771-88. (WB; Human) [PubMed:25596733] [PMC:PMC4359254]
2
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M. Cancer research. 2016 76:594-606. (WB; Human) [Full Text Article] [PubMed:26772755] [PMC:PMC4785885] Related Antibodies: LS-B10217.
3
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Kovacovicova K, Skolnaja M, Heinmaa M, Mistrik M, Pata P, Pata I, Bartek J, Vinciguerra M. Frontiers in oncology. 2018 October;8:459. [Full Text Article] [PubMed:30425964] [PMC:PMC6218402] Related Antibodies: LS-B10217.
4
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. Journal of neuroinflammation. 2018 September;15:260. [Full Text Article] [PubMed:30201019] [PMC:PMC6131894] Related Antibodies: LS-B10989.
5
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q Estrada, Simon Knott, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed. Cell reports. 2021 December;37:110068. [Full Text Article] [PubMed:34910915] [PMC:PMC8716125] Related Antibodies: LS-B10989.
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Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
GLB1 / Beta-Galactosidase (11)
No (11)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (2)
His-S (1)
Myc-DDK (Flag) (4)
Human (8)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (3)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.63kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.6 kDa
10 µg/$384; 50 µg/$557
GLB1 / Beta-Galactosidase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
75.9 kDa
100 µg/$494
GLB1 / Beta-Galactosidase Protein - 12.5% SDS-PAGE of human GLB1 stained with Coomassie Blue
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Wheat Germ Extract
GST
100.21 kDa
2 µg/$439
GLB1 / Beta-Galactosidase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GLB1 / Beta-Galactosidase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
75.9 kDa
20 µg/$150
GLB1 / Beta-Galactosidase Protein - Purified recombinant protein GLB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
75.9 kDa
20 µg/$1,107
GLB1 / Beta-Galactosidase Protein - Purified recombinant protein GLB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
72.6 kDa
20 µg/$1,107
GLB1 / Beta-Galactosidase Protein - Recombinant Galactosidase Beta By SDS-PAGE
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E. coli
His-S
23.4 kDa
10 µg/$249; 50 µg/$307; 100 µg/$385; 200 µg/$482; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
GLB1 / Beta-Galactosidase Protein - Recombinant Galactosidase Beta By SDS-PAGE
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E. coli
His
28.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
GLB1 / Beta-Galactosidase Protein - Recombinant Galactosidase Beta By SDS-PAGE
Select
E. coli
His
27.3 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).