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GLUL / Glutamine Synthetase

glutamate-ammonia ligase

GLUL / Glutamine Synthetase belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.

Gene Name: glutamate-ammonia ligase
Synonyms: GLUL, GLNS, Glutamate decarboxylase, Glutamate-ammonia ligase, Glutamine synthase, GS, Glutamate--ammonia ligase, Glutamine synthetase, PIG43, PIG59
Target Sequences: NM_002065 NP_002056.2 P15104

Publications (3)

1
GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism. Magesh Muthu, Ranjeet Kumar, Azharuddin Sajid Syed Khaja, Jonathan D Gilthorpe, Jenny L Persson, Anders Nordström. Cancers. 2019 Dec;11:1945. [Full Text Article] [PubMed:31817360] [PMC:PMC6966511] Related Antibodies: LS-C114787.
2
Toll-Like Receptor 9-Mediated Neuronal Innate Immune Reaction Is Associated with Initiating a Pro-Regenerative State in Neurons of the Dorsal Root Ganglia Non-Associated with Sciatic Nerve Lesion. Petr Dubový, Ivana Hradilová-Svíženská, Václav Brázda, Marek Joukal. International journal of molecular sciences. 2021 July;22:7446. [Full Text Article] [PubMed:34299065] [PMC:PMC8304752] Related Antibodies: LS-B2579.
3
Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve. Dubov[Character fd] P, Br[Character e1]zda V, Klus[Character e1]kov[Character e1] I, Hradilov[Character e1]-Sv[Character ed]ensk[Character e1] I. Journal of neuroinflammation. 2013 10:55. [Full Text Article] [PubMed:23634725] [PMC:PMC3657546] Related Antibodies: LS-B2579.

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (6)
Recombinant (12)
GLUL / Glutamine Synthetase (18)
No (18)
6His, C-terminus (2)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (4)
Myc-DDK (Flag) (9)
Hamster-Chinese (1)
Human (12)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (7)
HEK 293 Cells (6)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (2)
Select
E. coli
His
44.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
GLUL / Glutamine Synthetase Protein - 12.5% SDS-PAGE of human GLUL stained with Coomassie Blue
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Wheat Germ Extract
GST
66.77 kDa
10 µg/$479; 25 µg/$670
GLUL / Glutamine Synthetase Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
His
44.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.13kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
GLUL / Glutamine Synthetase Protein - Purified recombinant protein GLUL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$1,107
GLUL / Glutamine Synthetase Protein - Purified recombinant protein GLUL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$1,107
GLUL / Glutamine Synthetase Protein - Purified recombinant protein GLUL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$1,107
GLUL / Glutamine Synthetase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$150
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$150
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$150
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
100 µg/$494
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
100 µg/$494
GLUL / Glutamine Synthetase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
100 µg/$494
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.1 kDa
10 µg/$344; 50 µg/$584
GLUL / Glutamine Synthetase Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
E. coli
His
43.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).