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GPBAR1 / TGR5
G protein-coupled bile acid receptor 1
GPBAR1 / TGR5 is a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
| Gene Name: | G protein-coupled bile acid receptor 1 |
| Family/Subfamily: | GPCR , Bile Acids |
| Synonyms: | GPBAR1, BG37, GPR131, HGPCR19, M-BAR, GPCR19, TGR5, GPCR TGR5, HBG37, Membrane bile acid receptor |
| Target Sequences: | AB083601 NP_733800.1 Q8TDU6 |
Publications (2)
1
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism. Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL. The Journal of biological chemistry. 2017 June;292:11055-11069. (Human)
[Full Text Article]
[PubMed:28478385]
[PMC:PMC5491788]
Related Antibodies: LS-C47388.
2
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Molecular metabolism. 2018 May;11:84-95. (Human)
[Full Text Article]
[PubMed:29656109]
[PMC:PMC6001409]
Related Antibodies: LS-A1936.
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Antibodies
(19)
Type
Primary
(19)
Target
GPBAR1 / TGR5
(19)
Reactivity
Human
(19)
Mouse
(4)
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(4)
Chimpanzee
(3)
Application
IHC
(6)
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(5)
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(8)
Flo
(1)
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(4)
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(3)
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(1)
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rabbit
(18)
mouse
(1)
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(4)
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(3)
PathPlus Cancer
(2)
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IgG
(7)
IgG2b
(1)
Clonality
monoclonal mc
(1)
polyclonal pc
(18)
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409522
(1)
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(1)
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(1)
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(1)
Unconjugated
(16)
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(6)
Cytoplasmic Domain
(2)
aa298-330
(2)
30-110 aa, N-terminal
(1)
Internal
(1)
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(1)
aa11-60
(1)
aa250-300
(1)
Publications
No
(17)
Yes
(2)
Cancer
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Cancer
Fast Shipping
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
GPBAR1 / TGR5 Mouse anti-Human Monoclonal (409522) Antibody
Human
Flo
Unconjugated
100 µg/$896
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$460
Fast Shipping
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa11-60) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa298-330) Antibody
Human
IHC
Unconjugated
50 µl/$649
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa298-330) Antibody
Human
ELISA
Unconjugated
100 µg/$649
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa250-300) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$668
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
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