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G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Gene Name: | G protein-coupled receptor 75 |
Family/Subfamily: | GPCR , Orphan-A |
Synonyms: | GPR75, G protein-coupled receptor 75, GPR-chr2, WI31133, GPRchr2, WI-31133 |
Target Sequences: | NM_006794 NP_006785.1 O95800 |
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