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GPR75

G protein-coupled receptor 75

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Name: G protein-coupled receptor 75
Family/Subfamily: GPCR , Orphan-A
Synonyms: GPR75, G protein-coupled receptor 75, GPR-chr2, WI31133, GPRchr2, WI-31133
Target Sequences: NM_006794 NP_006785.1 O95800

Publications (1)

1
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease. Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M Coolen, Fan Fan, Richard J Roman. Frontiers in neurology. 2020 October;11:983. [Full Text Article] [PubMed:33013649] [PMC:PMC7499024] Related Antibodies: LS-A1589, LS-A1594.

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Products
Antibodies (38)
Primary (38)
GPR75 (38)
Human (38)
Mouse (10)
Rat (8)
Bat (3)
Bovine (7)
Chicken (4)
Chimpanzee (3)
Hamster (8)
Horse (11)
Monkey (10)
Pig (7)
Rabbit (9)
Xenopus (5)
Zebrafish (3)
IHC (13)
IHC-P (8)
WB (29)
ELISA (13)
ICC (1)
IF (3)
Peptide-ELISA (2)
rabbit (37)
mouse (1)
Product Group
GPCR Database Antibodies (6)
IHCPlus (6)
IgG (15)
IgG1 (1)
monoclonal mc (1)
polyclonal pc (37)
11n81 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (1)
Unconjugated (21)
C-Terminus (8)
aa396-425 (7)
aa270-319 (4)
aa468-517 (4)
350-430 aa, C-terminal (1)
3rd Cytoplasmic Domain (1)
Cytoplasmic Domain (1)
N-Terminus (1)
aa372-540 (1)
aa381-430 (1)
aa423-468 (1)
No (36)
Yes (2)
GPR75 Antibody - Anti-GPR75 antibody IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
GPR75 Antibody - Anti-GPR75 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Bovine, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
GPR75 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GPR75 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GPR75 Antibody - Anti-GPR75 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3-7 ug/ml.
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GPR75 Rabbit anti-Human Polyclonal (3rd Cytoplasmic Domain) Antibody
Xenopus, Bat, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
GPR75 Antibody - Western blot of GPR75 antibody
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GPR75 Rabbit anti-Human Polyclonal (350-430 aa, C-terminal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPR75 Antibody - Immunofluorescence analysis of LOVO cells, using GPR75 Antibody. The picture on the right is blocked with the synthesized peptide.
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GPR75 Rabbit anti-Human Polyclonal (aa381-430) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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GPR75 Mouse anti-Human Monoclonal (11n81) Antibody
Human
IHC
Unconjugated
100 µg/$896
GPR75 Antibody - Western blot analysis of GPR75 expression in A431 whole cells lysate. The lane on the left is treated with the antigen-specific peptide.
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GPR75 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GPR75 Antibody - GPR75 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GPR75 Antibody - GPR75 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rat, Horse, Human
WB
Biotin Conjugated
100 µl/$469
GPR75 Antibody - GPR75 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR75 Rabbit anti-Human Polyclonal (aa468-517) Antibody
Human
WB
Unconjugated
100 µl/$424
GPR75 Antibody - Anti-GPR75 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 4-7 ug/ml.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPR75 Antibody - Anti-GPR75 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 18 ug/ml.
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GPR75 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Bovine, Pig, Horse, Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPR75 Antibody - Anti-GPR75 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10-25 ug/ml.
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GPR75 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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GPR75 Rabbit anti-Human Polyclonal (aa423-468) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
50 µl/$321; 100 µl/$403
GPR75 Antibody - Immunohistochemistry of paraffin-embedded human testis using antibody at dilution of 1:100.
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GPR75 Rabbit anti-Human Polyclonal (aa372-540) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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GPR75 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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GPR75 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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GPR75 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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GPR75 Rabbit anti-Human Polyclonal (aa396-425) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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GPR75 Rabbit anti-Human Polyclonal (aa396-425) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
GPR75 Antibody - GPR75 antibody Western blot of HeLa lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR75 Rabbit anti-Human Polyclonal (aa270-319) Antibody
Human
WB
Unconjugated
100 µl/$424
GPR75 Antibody - GPR75 Antibody western blot of U937 cell line lysates (35 ug/lane). The GPR75 antibody detected the GPR75 protein (arrow).
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GPR75 Rabbit anti-Human Polyclonal (aa396-425) Antibody
Human
WB
Unconjugated
400 µl/$393
GPR75 Antibody - Peptide - + Immunofluorescence analysis of LOVO cells, using GPR75 antibody.
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GPR75 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
GPR75 Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using GPR75 Polyclonal Antibody at dilution of 1:95(×200)
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GPR75 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).